Origins of basal ganglia output signals in singing juvenile birds.
Origins of basal ganglia output signals in singing juvenile birds.
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歌唱幼鸟的基底神经节输出信号的起源。
DOI：
10.1152/jn.00635.2014
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发表时间：
2015
影响因子：
2.5
通讯作者：
Goldberg,JesseH
中科院分区：
文献类型：
--
作者：
Pidoux,Morgane;Bollu,Tejapratap;Riccelli,Tori;Goldberg,JesseH
在不同物种中，基底神经节 (BG) 内的复杂回路汇聚在苍白球输出神经元上，这些神经元表现出运动锁定的放电模式。然而，这些发射模式的起源仍然知之甚少。在鸣禽发出咿咿呀呀的声音时，BG 输出神经元与灵长类内部苍白球节中的神经元同源，在音节开始前的数十毫秒内均匀激活。为了测试这种非常均匀的 BG 输出信号的起源，我们记录了 baby 期间不同上游 BG 细胞类型的情况。在音节出现之前，在内部苍白球节段样神经元被激活的同时，假定的中型多棘神经元、快速尖峰和强直活跃的中间神经元也表现出短暂的速率增加。相反，与灵长类苍白球外节中发现的苍白球神经元同源的苍白球神经元表现出短暂的速率降低。为了测试这些信号的起源，我们在运动前核 HVC 的皮质纹状体输入损伤后进行了记录。 HVC 损伤很大程度上消除了这些音节锁定信号。总而言之，这些发现表明鸣禽 BG 在咿呀学语期间的音节计时信号具有惊人的同质性，并且与探索行为期间间接和超直接通路在将皮质输入转化为 BG 输出中的作用一致。
Across species, complex circuits inside the basal ganglia (BG) converge on pallidal output neurons that exhibit movement-locked firing patterns. Yet the origins of these firing patterns remain poorly understood. In songbirds during vocal babbling, BG output neurons homologous to those found in the primate internal pallidal segment are uniformly activated in the tens of milliseconds prior to syllable onsets. To test the origins of this remarkably homogenous BG output signal, we recorded from diverse upstream BG cell types during babbling. Prior to syllable onsets, at the same time that internal pallidal segment-like neurons were activated, putative medium spiny neurons, fast spiking and tonically active interneurons also exhibited transient rate increases. In contrast, pallidal neurons homologous to those found in primate external pallidal segment exhibited transient rate decreases. To test origins of these signals, we performed recordings following lesion of corticostriatal inputs from premotor nucleus HVC. HVC lesions largely abolished these syllable-locked signals. Altogether, these findings indicate a striking homogeneity of syllable timing signals in the songbird BG during babbling and are consistent with a role for the indirect and hyperdirect pathways in transforming cortical inputs into BG outputs during an exploratory behavior.