EFFECTS OF EXERCISE TRAINING ON CORONARY CIRCULATION - INTRODUCTION
EFFECTS OF EXERCISE TRAINING ON CORONARY CIRCULATION - INTRODUCTION
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DOI：
10.1249/00005768-199410000-00008
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发表时间：
1994-10-01
期刊：
影响因子：
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通讯作者：
LAUGHLIN, MH
中科院分区：
文献类型：
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作者：
LAUGHLIN, MH
本次研讨会的目的是评估训练的有益效果是训练诱导的冠状动脉循环适应的结果这一假设。方法是回顾、总结和评估有关运动训练对冠状动脉循环影响的数据。结果表明，有氧运动训练可引起血流容量和毛细血管交换容量的增加。这些功能变化是两种主要的适应性反应的结果：血管结构适应和血管阻力控制的改变。结构血管适应在运动训练后至少以两种形式发生：冠状动脉近端横截面积的增加和血管生成。训练引起的冠状动脉控制的变化已被证明包括冠状动脉循环和离体冠状动脉对血管活性物质的反应改变，内皮介导的血管调节的变化，以及从运动训练动物的冠状动脉分离的内皮细胞和血管平滑肌细胞中细胞内游离Ca2+的细胞分子控制的改变。这些训练诱导的适应对冠状动脉侧枝循环和动脉粥样硬化性冠状动脉疾病的潜在影响进行了讨论。
The purpose of this symposium was to evaluate the hypothesis that the beneficial effects of training are the result of training-induced adaptations in the coronary circulation. The approach is to review, summarize, and evaluate data concerning the effects of exercise training on the coronary circulation. Results indicate that aerobic exercise training induces an increase in both blood flow capacity and capillary exchange capacity. These functional changes are the result of two major types of adaptive responses: structural vascular adaptation and altered control of vascular resistance. Structural vascular adaptation occurs in response to exercise training in at least two forms: increases in the cross-sectional area of the proximal coronary arteries, and angiogenesis. Training-induced changes in coronary vascular control have been shown to include altered responses of the coronary circulation and isolated coronary arteries to vasoactive substances, changes in endothelium-mediated vasoregulation, and alterations in the cellular-molecular control of intracellular free Ca2+ in both endothelial and vascular smooth muscle cells isolated from coronary arteries of exercise trained animals. The potential impact of these training-induced adaptations on the coronary collateral circulation and atherosclerotic coronary disease are discussed.