Inducibility of thymic lymphomas in female Hsd: (ICR)BR mice following subcutaneous injection of ethyl- and isopropyl methanesulfonate.
Inducibility of thymic lymphomas in female Hsd: (ICR)BR mice following subcutaneous injection of ethyl- and isopropyl methanesulfonate.
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雌性 Hsd：（ICR）BR 小鼠皮下注射甲磺酸乙酯和甲磺酸异丙酯后胸腺淋巴瘤的诱导性。
DOI：
10.1016/0304-3835(89)90061-x
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发表时间：
1989
期刊：
影响因子：
9.7
通讯作者：
Sellakumar,A
中科院分区：
文献类型：
--
作者：
Segal,A;Sellakumar,A
以10 μmol/只小鼠的剂量每周一次皮下注射甲磺酸异丙酯（IMS）（一种直接作用的SN 1烷化剂）后第139天，在30只雌性Hsd：（ICR）BR小鼠中的29只中诱导胸腺淋巴瘤。在每周一次皮下注射（20 μmol/小鼠）52次临界SN 1/SN 2烷化剂甲磺酸乙酯（EMS）后的第450天，未观察到此类肿瘤。在30只EMS处理的小鼠中，2只观察到局部肉瘤，20只观察到肺腺瘤，其中70%在第450天存活。IMS治疗后，除胸腺外，在局部或远处部位均未观察到新生儿。结果表明造血组织对IMS引起的DNA损伤类型敏感。
Isopropyl methanesulfonate (IMS), a direct-acting SN1 alkylating agent, induced thymic lymphomas in 29 of 30 female Hsd: (ICR)BR mice by the 139th day following once a week subcutaneous injections at a dose of 10 μmol/mouse. No such neoplasms were observed at the 450th day following 52 once a week subcutaneous injections (20 μmol/mouse) of the borderline SN1/SN2 alkylating agent ethyl methanesulfonate (EMS). Local sarcomas were observed in 2 and pulmonary adenomas in 20 of the 30 EMS-treated mice, 70% of which were alive at the 450th day. Neoplasms were not observed at local or at distant sites other than the thymus gland following treatment with IMS. The results suggest a sensitivity of hemopoietic tissue to the types of DNA lesions induced by IMS.