Power spectral analysis of heart rate variability in children and adolescents with IDDM
Power spectral analysis of heart rate variability in children and adolescents with IDDM
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DOI：
10.2337/diacare.20.9.1416
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发表时间：
1997-09-01
期刊：
影响因子：
16.2
通讯作者：
Couper, JJ
中科院分区：
文献类型：
--
作者：
Wawryk, AM;Bates, DJ;Couper, JJ
目的-探讨功率谱分析（PSA）的心率变异性（HRV）在儿童和青少年与胰岛素依赖型糖尿病，其与其他措施的HRV和标准的心血管反应，与减少HVR.RESEARCH设计和方法的相关因素-共130名年龄为12.8 +/- 3.2岁的胰岛素依赖型糖尿病和108名健康对照组进行了研究。功率谱分析从仰卧心电图（EGG）记录处理成连续的R-R间期和分析，使用快速傅立叶变换。深呼吸和站立的标准心血管反应进行了。结果- IDDM受试者的总功率减少，包括低频（0.05-0.14 Hz; P = 0.0001）和高频（0.14-0.40 Hz; P = 0.0002）组件。这些变化是从诊断中看到的。其他心率变异性指标，平均静息心率的变异系数（CV）和标准差（SD），在胰岛素依赖型糖尿病患者中也显著降低。所有20（15%）的130名总功率小于第5百分位数的对照组的胰岛素依赖型糖尿病患者也有降低的心率变异性时，测量的CV的心率。有一个独立的年龄和高频率成分之间的关系，在胰岛素依赖型糖尿病受试者和对照组。总功率与平均心率（r = 0.56; P < 0.0001）、心率CV（r = 0.90; P < 0.00001）、心率SD（r = 0.91; P < 0.00001）、深呼吸心率反应（r = 0.45; P < 0.0001）和持续时间相关。与短期或长期代谢控制无关。重新测试的27名受试者表现出变异性的总功率和其组成部分相媲美的HRV和标准心率responses.CONCLUSIONS -HRV的变化是一个敏感的和可重复的措施，在儿童早期自主神经功能障碍。在这个年龄组中，PSA作为HRV降低的指标并不比其他密切相关的HRV指标更敏感。
OBJECTIVE - To investigate power spectral analysis (PSA) of heart rate variability (HRV) in children and adolescents with IDDM, its relationship with other measures of HRV and standard cardiovascular responses, and factors associated with reduced HVR.RESEARCH DESIGN AND METHODS - A total of 130 subjects with IDDM aged 12.8 +/- 3.2 years and 108 healthy control subjects were studied. Power spectra were analyzed from supine electrocardiograph (EGG) recordings by processing into consecutive R-R intervals and analysis using fast Fourier transformation. Standard cardiovascular responses to deep breathing and standing were performed.RESULTS - IDDM subjects had a reduction in total power including both low-frequency (0.05-0.14 Hz; P = 0.0001) and high-frequency (0.14-0.40 Hz; P = 0.0002) components. These changes were seen from diagnosis. Other measures of HRV, coefficient of variation (CV) and standard deviation (SD) of mean resting heart rate, were also significantly lower in IDDM. All 20 (15%) of the 130 IDDM subjects with total power less than the 5th percentile in control subjects also had reduced HRV when measured by CV of heart rate. There was an independent relationship between age and the high-frequency component in IDDM subjects and control subjects. Total power correlated with mean heart rate (r = 0.56; P < 0.0001), CV of heart rate (r = 0.90; P < 0.00001), SD of heart rate (r = 0.91; P < 0.00001), heart rate response to deep breathing (r = 0.45; P < 0.0001), and duration in IDDM subjects. There was no correlation with short-term or long-term metabolic control. Retesting of 27 subjects showed a variability in total power and its components comparable to other measures of HRV and standard heart rate responses.CONCLUSIONS - Changes in HRV are a sensitive and reproducible measure of early autonomic dysfunction in childhood. In this age-group, PSA appears no more sensitive a measure of reduced HRV than other closely correlated measures of HRV.