Progestogen-Only Contraceptives and the Risk of Stroke A Meta-Analysis
Progestogen-Only Contraceptives and the Risk of Stroke A Meta-Analysis
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DOI：
10.1161/strokeaha.108.538405
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发表时间：
2009-04-01
期刊：
影响因子：
8.3
通讯作者：
Plu-Bureau, Genevieve
中科院分区：
文献类型：
--
作者：
Chakhtoura, Zeina;Canonico, Marianne;Plu-Bureau, Genevieve
背景和目的：联合口服避孕药（OC）的使用与卒中风险增加之间的关联已被报道。虽然孕激素避孕药（POC）在世界范围内普遍使用，但其对心血管疾病的影响尚不清楚。方法：基于EMBASE和MEDLINE参考文献对1960年以来上市的OCs进行meta分析。我们回顾了评估与OC或POC相关的卒中风险的符合条件的文章，并提取了相关研究。meta分析考虑了所有类型的POC和给药途径。结果：确定了6项病例对照研究。综合奇比（OR）显示POC使用者卒中风险没有增加（OR=0.96； 95%可信区间：0.70 ~ 1.31）。根据给药途径（种植或注射或口服POC），结果相似。结论：来自观察性研究的数据表明，POC的使用与卒中风险增加无关。然而，这些结果是基于有限的数据。有中风危险因素的妇女需要进一步调查。(中风。2009;40:1059 - 1062)。
Background and Purpose-The association between combined oral contraceptives (OC) use and increased risk of stroke has been reported. While progestogen-only contraceptives (POC) are commonly used worldwide, their impact on cardiovascular disease remains unclear.Methods-A meta-analysis based on EMBASE and MEDLINE referenced literature corresponding to OCs marketed since 1960 was carried out. Eligible articles assessing the risk of stroke in relation to OC or POC were reviewed, and relevant studies were extracted. All types of POC and routes of administration were taken into account in the meta-analysis.Results-Six case-control studies were identified. The combined odd ratio (OR) showed no increase in the risk of stroke among POC users (OR=0.96; 95% confidence interval: 0.70 to 1.31). This result was similar according to the route of administration (either implant or injectable or oral POC).Conclusion-Data from observational studies show that POC use is not associated with an increased risk of stroke. However, these results are based on limited data. Further investigations are needed in women with risk factors of stroke. (Stroke. 2009;40:1059-1062.)