Investigating the relationship between hyposalivation and mucosal wetness
Investigating the relationship between hyposalivation and mucosal wetness
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DOI：
10.1111/j.1601-0825.2010.01715.x
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发表时间：
2011-01-01
期刊：
影响因子：
3.8
通讯作者：
Proctor, G. B.
中科院分区：
文献类型：
--
作者：
Osailan, S.;Pramanik, R.;Proctor, G. B.
背景：口腔黏膜湿润度（MW）反映了口腔黏膜表面残留的唾液层，目的：本研究旨在测定不同口腔黏膜部位的MW，并探讨MW、非刺激性全唾液流率（UWS）和临床口腔干燥评分（CODS）之间的关系。用滤纸条在口腔内的四个部位（前硬腭（AHP）、颊粘膜（布克）、前舌（AT）、下唇（LL））对MW进行取样，并用微量水分计测量。结果：在健康受试者的粘液湿度不同，根据网站和平均值+/- SD为：AHP（11 +/- 11.7亩米），布克（32 +/- 14.8亩米），AT（65 +/- 17.2亩米），和LL（25 +/- 13.5亩米）。UWS降低的口干患者表现为CODS增加。与健康对照组相比，口干患者四个部位的MW均显著降低（P < 0.05）。使用组内相关系数的MW测量重现性显示受试者内不同访视时的一致性。结论：口腔黏膜湿润度与UWS呈正相关，是口腔干燥的可靠指标。
Background:Mucosal wetness (MW) reflects the layer of residual saliva that covers the oral mucosal surfaces.Objectives:The aim of this study was to determine MW at different oral mucosa sites and to investigate the relationship between MW, unstimulated whole salivary flow rates (UWS) and Clinical Oral Dryness Score (CODS).Method:A total of 100 dry mouth patients and 50 healthy subjects participated in the study. MW was sampled with filter paper strips at four sites inside the mouth; anterior hard palate (AHP), buccal mucosa (BUC), anterior tongue (AT), lower lip (LL) and measured with a micro-moisture meter. Reproducibility was assessed by repeated sampling and diurnal variation was examined.Results:Mucosal wetness in healthy subjects differed according to site and means +/- SD were; AHP (11 +/- 11.7 mu m), BUC (32 +/- 14.8 mu m), AT (65 +/- 17.2 mu m), and LL (25 +/- 13.5 mu m). Dry mouth patients with reduced UWS showed increased CODS. MW at all four sites was significantly reduced (P < 0.05) in dry mouth patients compared with the healthy subjects. Reproducibility of MW measurement using the intra-class correlation coefficient showed agreement at different visits within subject. MW of the AT showed a positive correlation with UWS (P < 0.05).Conclusion:Mucosal wetness is a reliable measure of oral dryness and had a positive correlation with UWS.