Common and well-documented (CWD) alleles of human leukocyte antigen-A, -B, -C, -DRB1, and -DQB1 loci for the Chinese Han population do not quite correlate with the ASHI CWD alleles
Common and well-documented (CWD) alleles of human leukocyte antigen-A, -B, -C, -DRB1, and -DQB1 loci for the Chinese Han population do not quite correlate with the ASHI CWD alleles
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中国汉族人群中人类白细胞抗原 A、-B、-C、-DRB1 和 -DQB1 基因座的常见且有据可查的 (CWD) 等位基因与 ASHI CWD 等位基因不太相关
DOI：
10.1016/j.humimm.2011.06.005
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发表时间：
2012-01-01
期刊：
影响因子：
2.7
通讯作者：
Hou, Jianquan
中科院分区：
文献类型：
--
作者：
He, Jun;Li, Yang;Hou, Jianquan
人类白细胞抗原（HLA）具有极其多态性，在干细胞移植中发挥着重要作用。中国汉族人口约 13 亿，其 HLA 等位基因多种多样，需要对其进行表征。中国骨髓捐赠计划 (CMDP) 提供了 3,296 名独立、无亲属关系的中国汉族个体（1,457 名受赠者和 1,839 名捐献者）的数据，用于供者-受者确认分型。采用基于序列的分型、序列特异性寡核苷酸探针（SSOP）/高清晰度-SSOP和序列特异性引物方法来获得4位等位基因。总共观察到 49、86、50、63 和 24 个 HLA-A、-B、-C、-DRB1 和 -DQB1 等位基因。根据美国组织相容性和免疫遗传学学会 (ASHI) 通用且有据可查的 (CWD) 标准，我们的实验室测试和其他实验室报告中中国汉族的 CWD 等位基因与 ASHI CWD 等位基因不太相关：A*11:53、A*02:34、A*02:53N、B*27:24、B*46:02、B*55:12、 C*01:06、C*03:17、C*06:06、C*07:66、C*07:67、C*08:22、DRB1*12:10、DQB1*03:13 和 DQB1*06:05 是 CWD，但不包含在 ASHI CWD 列表中。一系列等位基因是有详细记录的等位基因，并列在 ASHI CWD 列表中。相反，A*26:03、B*51:03、C*12:05、C*15:09、C*15:11、C*17:03、DRB1*11:07、DRB1*11:11、DRB1*13:05、DRB1*13:13、DRB1*14:06、DRB1*14:12、 DRB1*14:22、DRB1*14:25 和 DQB1*06:11 是罕见等位基因，但包含在 ASHI CWD 列表中。 HLA种族多样性是全球HLA等位基因差异的主要原因。 ASHI HLA CWD 等位基因有助于减少高分辨率捐献者登记处的工作量和费用，HLA 等位基因频率为预测找到 HLA 匹配捐献者的机会提供了基础。我们的数据对于 CMDP、全球其他捐助者登记处以及更新的 ASHI CWD 等位基因列表都有意义。 (C) 2012 年美国组织相容性和免疫遗传学学会。由爱思唯尔公司出版。保留所有权利。
Human leukocyte antigen (HLA), which is extremely polymorphic, plays an important role in stem cell transplantation. The Chinese Han comprise a large population of approximately 1.3 billion with diverse HLA alleles that need to be characterized. Data from 3,296 independent, unrelated Chinese Han individuals (1,457 recipients and 1,839 donors) were provided by the China Marrow Donor Program (CMDP) for donor-recipient confirmatory typing. Sequence-based typing, sequence-specific oligonucleotide probe (SSOP)/High Definition-SSOP, and sequence-specific primer methods were used to obtain 4-digit alleles. A total of 49, 86, 50, 63, and 24 HLA-A, -B, -C, -DRB1, and -DQB1 alleles were observed. Following American Society for Histocompatibility and Immunogenetics (ASHI) common and well-documented (CWD) criteria, CWD alleles for Chinese Han in our laboratory test and other laboratory reports do not quite correlate with the ASHI CWD alleles: A*11:53, A*02:34, A*02:53N, B*27:24, B*46:02, B*55:12, C*01:06, C*03:17, C*06:06, C*07:66, C*07:67, C*08:22, DRB1*12:10, DQB1*03:13, and DQB1*06:05 are CWD, but are not included in the ASHI CWD list. A series of alleles are well-documented alleles and are listed in the ASHI CWD list. Conversely, A*26:03, B*51:03, C*12:05, C*15:09, C*15:11, C*17:03, DRB1*11:07, DRB1*11:11, DRB1*13:05, DRB1*13:13, DRB1*14:06, DRB1*14:12, DRB1*14:22, DRB1*14:25, and DQB1*06:11 are rare alleles, but are included in the ASHI CWD list. HLA ethnic diversity is the main reason for the differences in HLA alleles worldwide. The ASHI HLA CWD alleles help reduce the workload and expenses in high-resolution donor registries and the HLA allele frequencies provide a basis from which to predict the chances of finding HLA matching donors. Our data will be meaningful for the CMDP, for other worldwide donor registries, and for an updated ASHI CWD allele list. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.