Aqueous Solubilization of Fullerenes Using Poly(amidoamine) Dendrimers Bearing Cyclodextrin and Poly(ethylene Glycol)
Aqueous Solubilization of Fullerenes Using Poly(amidoamine) Dendrimers Bearing Cyclodextrin and Poly(ethylene Glycol)
复制标题
DOI：
10.1021/bc8001503
复制
发表时间：
2008-11-01
影响因子：
4.7
通讯作者：
Kono, Kenji
中科院分区：
文献类型：
--
作者：
Kojima, Chic;Toi, Yoko;Kono, Kenji
富勒烯具有独特的结构和显著的化学和物理性质，在包括生物应用在内的各个领域都得到了广泛的研究。富勒烯在水中极差的溶解性限制了它们在生物医学上的应用。在本研究中，我们合成了同时含有β-环糊精(CD)和聚乙二醇(PEG)的聚酰胺胺树枝状大分子，并用核磁共振氢谱、红外光谱和凝胶渗透色谱对所得树枝状大分子进行了表征。我们用这些树枝状大分子制备了2.8亩M的富勒烯水溶液。环糊精和聚乙二醇单分子在树枝状大分子表面的聚集作用可能是富勒烯增溶的关键。
Fullerene has a unique structure and notable chemical and physical properties, which have been studied in diverse fields including biological applications. The extremely poor solubility of fullerenes in water limits their usage for biomedical applications. In this study, we synthesized polyamidoamine dendrimers having both beta-cyclodextrin (CD) and poly(ethylene glycol) (PEG) and characterized the resulting dendrimers by H-1 NMR, IR, and gel permeation chromatography. We prepared 2.8 mu M of aqueous fullerene solutions using these dendrimers. The clustering effect of CD and PEG at the surface of the dendrimer might be crucial for the solubilization of fullerene.