ATRIAL NATRIURETIC FACTOR-SV40 T-ANTIGEN TRANSGENES PRODUCE TUMORS AND CARDIAC-ARRHYTHMIAS IN MICE
ATRIAL NATRIURETIC FACTOR-SV40 T-ANTIGEN TRANSGENES PRODUCE TUMORS AND CARDIAC-ARRHYTHMIAS IN MICE
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DOI：
10.1126/science.2964082
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发表时间：
1988-02-26
期刊：
影响因子：
56.9
通讯作者：
FIELD, LJ
中科院分区：
文献类型：
--
作者：
FIELD, LJ
产生了携带心房利钠因子（一种密切参与血压调节的激素）转录调控序列和编码sv40t抗原（一种单蛋白）转录调控序列融合的转基因小鼠。虽然两个心房都表达融合基因，但对T抗原的病理反应是不对称的。右心房的质量增加了几百倍，而左心房的大小保持相对正常。增生伴随着心房传导系统异常的频率和严重程度的逐渐增加，最终导致死亡。
Transgenic mice that carry fusions between the transcriptional regulatory sequences of atrial natriuretic factor (a hormone intimately involved in the regulation of blood pressure) and those encoding SV40 T antigen (an onoprotein) were generated. Although both atria express the fusion gene, the pathological response to T antigen is asymmetrical. The right atrium undergoes a several hundredfold increase in mass while the left atrium remains relatively normal in size. Hyperplasia is accompanied by a progressive increase in both the frequency and severity of abnormalities in the atrial conduction system, which ultimately result in death.