Chromosomal mapping of the second human CD8B gene locus.
Chromosomal mapping of the second human CD8B gene locus.
复制标题
第二个人类 CD8B 基因位点的染色体作图。
DOI：
10.1007/bf00587303
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发表时间：
1996
期刊：
影响因子：
3.2
通讯作者：
Chamberlain,JW
中科院分区：
文献类型：
--
作者：
Zhang,XL;Heng,HH;Yang,Y;Tsui,LC;Parnes,JR;Chamberlain,JW
由大多数T淋巴细胞表达的c~ 3 T细胞受体（TCR）识别与主要组织相容性复合体（MHC; Germain 1994）编码的I类或II类蛋白相关的外源抗原（Ag）。CD 8和CD 4是由不同的T细胞亚群表达的分子，并且被称为T细胞共受体，因为它们在这些识别事件中帮助TCR（Parnes 1989; Miceli和Parnes 1993）。这些共受体的相互排斥的表达模式区分了c-TCR T细胞的两个亚系：识别与I类MHC结合的Ag的CD 8 + CD 4-/细胞毒性T细胞和识别与II类MHC结合的Ag的CD 8-CD 4 +/辅助性T细胞。（Germain 1994; Miceli等1994）_CD 8（通常表达为CD 8+和CD 8+链的异源二聚体）和CD 4在T细胞成熟期间经历复杂的调控表达模式。在胸腺中，最不成熟的细胞从既不表达CD 8也不表达CD 4（双阴性/DN阶段）进展到两者共表达的中间阶段（双阳性/DP阶段）。作为胸腺选择和进一步分化的结果，DP细胞产生最成熟的胸腺细胞，最后产生外周T细胞，其是MHC I类限制性CD 8 + CD 4-CTL或MHC II类限制性CD 8-CD 4+辅助细胞（yon Boehmer 1988; Rothenberg 1992）。
The c~ 3 T-cell receptor (TCR) expressed by most T lymphocytes recognizes foreign antigen (Ag) associated with class I or class II proteins encoded by the major histocompatibility complex (MHC; Germain 1994). CD8 and CD4 are molecules expressed by distinct subsets of T cells and are referred to as T-cell co-receptors because they aid the TCR in these recognition events (Parnes 1989; Miceli and Parnes 1993). The mutually exclusive pattern of expression of these co-receptors distinguishes the two sublineages of c~ TCR T cells: CD8+ CD4-/cytotoxic T cells which recognize Ag bound to class I MHC, and CD8-CD4+/helper T cells which recognize Ag bound to class II MHC (Germain 1994; Miceli et al. 1994) _ CD8 (usually expressed as a heterodimer of CD8c~ and CD8 [~ chains) and CD4 undergo a complex pattern of regulated expression during T-cell maturation. In the thymus, the most immature cells progress from expressing neither CD8 nor CD4 (the double-negative/DN stage) to an intermediate stage at which both are co-expressed (the double-positive/DP stage). As a result of thymic selection and further differentiation, DP cells give rise to the most mature thymic cells, and finally, to peripheral T cells which are either MHC class I-restricted CDS+ CD4-CTL or MHC class II-restricted CD8-CD4+ helpers (yon Boehmer 1988; Rothenberg 1992).