Evaluation of a Records-Review Surveillance System Used to Determine the Prevalence of Autism Spectrum Disorders
Evaluation of a Records-Review Surveillance System Used to Determine the Prevalence of Autism Spectrum Disorders
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DOI：
10.1007/s10803-010-1050-7
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发表时间：
2011-02-01
影响因子：
3.9
通讯作者：
Yeargin-Allsopp, Marshalyn
中科院分区：
文献类型：
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作者：
Avchen, Rachel Nonkin;Wiggins, Lisa D.;Yeargin-Allsopp, Marshalyn
我们开展了第一项研究，对美国疾病控制与预防中心开发的一个基于人群的自闭症谱系障碍（ASD）监测系统的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）进行了评估。该系统采用一种记录审查方法，得出自闭症谱系障碍分类（病例与非自闭症谱系障碍病例），并与基于临床检查的分类进行了比较。这项研究招募了177名儿童。估计的特异性（0.96，[95%置信区间 = 0.94，0.99]）、阳性预测值（0.79 [95%置信区间 = 0.66，0.93]）和阴性预测值（0.91 [95%置信区间 = 0.87，0.96]）都较高。敏感性较低（0.60 [95%置信区间 = 0.45，0.75]）。鉴于诊断的异质性以及人群中自闭症谱系障碍的广泛多样性，识别自闭症谱系障碍儿童具有挑战性。基于记录的监测得出的基于人群的自闭症谱系障碍估计值可能是保守的。
We conducted the first study that estimates the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of a population-based autism spectrum disorders (ASD) surveillance system developed at the Centers for Disease Control and Prevention. The system employs a records-review methodology that yields ASD classification (case versus non-ASD case) and was compared with classification based on clinical examination. The study enrolled 177 children. Estimated specificity (0.96, [CI.95 = 0.94, 0.99]), PPV (0.79 [CI.95 = 0.66, 0.93]), and NPV (0.91 [CI.95 = 0.87, 0.96]) were high. Sensitivity was lower (0.60 [CI.95 = 0.45, 0.75]). Given diagnostic heterogeneity, and the broad array of ASD in the population, identifying children with ASD is challenging. Records-based surveillance yields a population-based estimate of ASD that is likely conservative.