Cancer-Related Unconventional Protein Secretion: A New Role of the Endoplasmic Reticulum
Cancer-Related Unconventional Protein Secretion: A New Role of the Endoplasmic Reticulum
复制标题
癌症相关的非常规蛋白质分泌：内质网的新作用
DOI：
10.1089/dna.2023.0044
复制
发表时间：
2023
影响因子：
3.1
通讯作者：
Yoshida Kiyotsugu
中科院分区：
文献类型：
--
作者：
Yamada Kohji;Yoshida Kiyotsugu
非常规蛋白分泌（UPS）是控制缺乏信号肽的胞质蛋白定位的关键机制，与炎症、神经退行性疾病和癌症有关。先前对免疫细胞的几项研究已经证实了UPS的机制。在癌症中，一些细胞质蛋白的活跃分泌，包括PKCδ和核蛋白，已经被描述。此外，我们最近已经证明，扩展突触蛋白1，内质网的膜蛋白之一，在肝癌细胞的UPS中起关键作用。重要的是，癌细胞中的UPS显示出与以前已知的UPS明显不同的特征，因此，我们将它们归类为癌症相关UPS （CUPS）。在本文中，我们概述了UPS机制，并讨论了将癌症特异性UPS命名为CUPS的过程。
Unconventional protein secretion (UPS) is a crucial mechanism controlling the localization of cytosolic proteins lacking signal peptides and is implicated in inflammation, neurodegenerative diseases, and cancer. Several previous studies on immune cells have demonstrated the mechanisms of UPS. In cancer, the active secretion of several cytosolic proteins, including PKCδ and nucleolin, has been described. Moreover, we have recently demonstrated that extended synaptotagmin 1, one of the membrane proteins of the endoplasmic reticulum, plays a critical role in UPS in liver cancer cells. Importantly, UPS in cancer cells shows characteristics that are markedly different from those of the previously known UPS, and therefore, we categorize them as cancer-related UPS (CUPS). In this article, we provide an overview of UPS mechanisms and discuss the process that leads to the naming of cancer-specific UPS as CUPS.