Significance of vascular endothelial growth factor in growth and peritoneal dissemination of ovarian cancer.
Significance of vascular endothelial growth factor in growth and peritoneal dissemination of ovarian cancer.
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DOI：
10.1007/s10555-011-9337-5
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发表时间：
2012-06
影响因子：
9.2
通讯作者：
Pourgholami, Mohammad H.
中科院分区：
文献类型：
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作者：
Moghaddam, Samar Masoumi;Amini, Afshin;Morris, David L.;Pourgholami, Mohammad H.
关键词：
血管内皮生长因子（VEGF）是血管生成的关键调节因子，其驱动内皮细胞存活、增殖和迁移，同时增加血管通透性。VEGF在正常卵巢的生理学中起重要作用，也与卵巢癌的发病机制有关。VEGF主要通过促进肿瘤血管生成和增强血管通透性，促进与恶性腹水形成相关的腹膜癌转移的发展，这是诊断时晚期卵巢癌的特征。在实验和临床研究中，VEGF水平与生存率呈负相关。此外，VEGF抑制已显示抑制肿瘤生长和腹水产生，并抑制肿瘤侵袭和转移。这些发现为靶向VEGF信号通路的药物在卵巢癌患者中的临床评价奠定了基础。在这篇综述中，我们将重点关注VEGF参与卵巢癌的病理生理及其对疾病进展和传播的贡献。
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis which drives endothelial cell survival, proliferation, and migration while increasing vascular permeability. Playing an important role in the physiology of normal ovaries, VEGF has also been implicated in the pathogenesis of ovarian cancer. Essentially by promoting tumor angiogenesis and enhancing vascular permeability, VEGF contributes to the development of peritoneal carcinomatosis associated with malignant ascites formation, the characteristic feature of advanced ovarian cancer at diagnosis. In both experimental and clinical studies, VEGF levels have been inversely correlated with survival. Moreover, VEGF inhibition has been shown to inhibit tumor growth and ascites production and to suppress tumor invasion and metastasis. These findings have laid the basis for the clinical evaluation of agents targeting VEGF signaling pathway in patients with ovarian cancer. In this review, we will focus on VEGF involvement in the pathophysiology of ovarian cancer and its contribution to the disease progression and dissemination.
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影响因子：
5.2
作者：
Belotti, Dorina;Calcagno, Catia;Tarabolettl, Giulia
通讯作者：
Tarabolettl, Giulia
影响因子：
45.3
作者：
Burger, Robert A.;Sill, Michael W.;Sorosky, Joel I.
通讯作者：
Sorosky, Joel I.
影响因子：
2.6
作者：
Bussen, Stefanie;Bussen, Dieter
通讯作者：
Bussen, Dieter
影响因子：
15.3
作者：
BROWN, LF;YEO, KT;BERSE, B;YEO, TK;SENGER, DR;DVORAK, HF;VANDEWATER, L
通讯作者：
VANDEWATER, L
DOI：
10.1200/jco.2007.10.8332
发表时间：
2008-08-01
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
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作者：
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