Long-Term Effects of Nanoparticles on Nutrition and Metabolism
Long-Term Effects of Nanoparticles on Nutrition and Metabolism
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纳米颗粒对营养和代谢的长期影响
DOI：
10.1002/smll.201303635
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发表时间：
2014-09-24
期刊：
影响因子：
13.3
通讯作者：
Song, Haiyun
中科院分区：
文献类型：
--
作者：
Chen, Nan;Wang, Hui;Song, Haiyun
纳米粒子由于其独特的物理和化学性质，在生物学和生物医学应用中显示出巨大的潜力。与此同时，纳米粒子的生物安全性也引起了世界范围内的强烈关注。为了解决这些问题，已经做出了很大的努力来检查纳米颗粒对细胞存活和增殖的短期影响。最近，探索纳米材料的长期影响，特别是那些有前途的生物医学应用在体内，引起了极大的兴趣。例如，金纳米颗粒（AuNPs）通常被认为对细胞生长无毒，而最近的研究表明，AuNPs可能对细胞代谢和能量稳态具有长期影响。本文综述了这方面的最新进展。此外，可能的机制下，纳米粒子调节代谢信号通路，对细胞合成代谢或分解代谢过程的潜在长期影响，以及它们在人类健康和代谢紊乱的影响进行了讨论。
Nanoparticles have shown great potential in biological and biomedical applications due to their distinct physical and chemical properties. In the meanwhile, the biosafety of nanoparticles has also raised intense concerns worldwide. To address such concerns, great efforts have been made to examine short-term effects of nanoparticles on cell survival and proliferation. More recently, exploration of long-term effects of nanomaterials, particularly those with promising biomedical applications in vivo, has aroused significant interest. For example, gold nanoparticles (AuNPs) are generally considered non-toxic to cell growth, whereas recent studies suggest that AuNPs might have long-term effects on cellular metabolism and energy homeostasis. In this Review, recent advances in this direction are summarized. Further, possible mechanisms under which nanoparticles regulate metabolic signaling pathways, potential long-term effects on cellular anabolic or catabolic processes, and their implications in human health and metabolic disorders are discussed.