Avian influenza virus exhibits rapid evolutionary dynamics
Avian influenza virus exhibits rapid evolutionary dynamics
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禽流感病毒呈现快速进化动态
DOI：
10.1093/molbev/msl102
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发表时间：
2006-12-01
影响因子：
10.7
通讯作者：
Holmes, Edward C.
中科院分区：
文献类型：
--
作者：
Chen, Rubing;Holmes, Edward C.
来自野生水生鸟类（其天然宿主物种）的甲型流感病毒被认为已经达到一种停滞状态，其特征是进化变化率低。我们测试了这一假设，估计在一个不同的阵列的禽流感病毒（AIV）的核苷酸取代率，并允许率的变化之间的谱系。观察到的发生率极高，每年每个位点> 10（-3）个替换，野生和家养宿主物种或病毒亚型之间几乎没有差异，与哺乳动物甲型流感病毒中观察到的相似。因此，甲型流感病毒在其宿主范围内表现出快速进化动力学，与高背景突变率和快速复制一致。使用同样的方法，我们还估计AIV的血凝素和神经氨酸酶序列的共同祖先出现在过去的3,000年内，大多数亚型内的多样性出现在过去的100年内，并暗示了持续的选择性更替。
Influenza A viruses from wild aquatic birds, their natural reservoir species, are thought to have reached a form of stasis, characterized by low rates of evolutionary change. We tested this hypothesis by estimating rates of nucleotide substitution in a diverse array of avian influenza viruses (AIV) and allowing for rate variation among lineages. The rates observed were extremely high, at > 10(-3) substitutions per site, per year, with little difference among wild and domestic host species or viral subtypes and were similar to those seen in mammalian influenza A viruses. Influenza A virus therefore exhibits rapid evolutionary dynamics across its host range, consistent with a high background mutation rate and rapid replication. Using the same approach, we also estimated that the common ancestors of the hemagglutinin and neuraminidase sequences of AIV arose within the last 3,000 years, with most intrasubtype diversity emerging within the last 100 years and suggestive of a continual selective turnover.