Reference ranges for uterine artery mean pulsatility index at 11-41 weeks of gestation
Reference ranges for uterine artery mean pulsatility index at 11-41 weeks of gestation
复制标题
DOI：
10.1002/uog.5315
复制
发表时间：
2008-08-01
影响因子：
7.1
通讯作者：
Gratacos, E.
中科院分区：
文献类型：
--
作者：
Gomez, O.;Figueras, F.;Gratacos, E.
目的建立基于孕龄（GA）的11 - 41周子宫动脉（UtA）平均搏动指数（PI）参考值范围。通过彩色和脉冲多普勒成像检查UtA，并记录平均PI以及是否存在双侧舒张前切迹。多项式拟合通过最小二乘回归估计UtA-Pl和GA的平均值之间的关系。在自然对数转换后，选择二次多项式（Log，平均UtA-Pl = 1.39-0.012 x GA + GA（2）x 0.0000198，GA以天为单位测量）来模拟我们的数据。在11周（平均PI，1.79;第95百分位数，2.70）和34周（平均PI，0.70;第95百分位数，0.99）之间，平均UtA-PI显著降低。然后，它变得更加稳定，直到41周（平均PI，0.65; 95（第）百分位数，0.89）。结论平均UtA-PI显示了一个渐进的下降，直到妊娠晚期。平均UtA-Pl的参考范围可能在妊娠晚期筛查胎盘相关疾病和评估妊娠高血压患者和/或小于胎龄胎儿方面具有临床价值。Copyrigbt（C）2008 ISUOG.由John Wiley & Sons有限公司出版
Objectives To construct gestational age (GA)-based reference ranges for the uterine artery (UtA) mean pulsatility index (PI) at 11-41 weeks of pregnancy.Methods A prospective cross-sectional observational study was carried out of 20 consecutive singleton pregnancies for each completed gestational week at 11-41 weeks. UtAs were examined by color and pulsed Doppler imaging, and the mean PI, as well as the presence or absence of a bilateral protodiastolic notch, were recorded. Polynomials were fitted by means of least-square regression to estimate the relationship between the mean UtA-Pl and GA.Results A total of 620 women were included. A second-degree polynomial (Log, mean UtA-Pl = 1.39-0.012 x GA + GA(2) x 0.0000198, with GA measured in days), after a natural logarithmic transformation, was selected to model our data. There was a significant decrease in the mean UtA-Pl between 11 weeks (mean PI, 1.79; 95(th) centile, 2.70) and 34 weeks (mean Pl, 0.70; 95(th) centile, 0.99). It then became more stable up until 41 weeks (mean Pl, 0.65; 95(th) centile, 0.89).Conclusions The mean UtA-Pl shows a progressive decrease until the late stages of pregnancy. Reference ranges for mean UtA-Pl may have clinical value in screening for placenta-associated diseases in the earl), stages of pregnancy, and in evaluating patients with pregnancy-induced hypertension and/or small-for-gestational age fetuses during the third trimester. Copyrigbt (C) 2008 ISUOG. Published by John Wiley & Sons, Ltd.