Tissue-Specific Control of Tissue-Resident Memory T Cells.
Tissue-Specific Control of Tissue-Resident Memory T Cells.
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DOI：
10.1615/critrevimmunol.2018025653
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发表时间：
2018
影响因子：
1.3
通讯作者：
Zhang N
中科院分区：
文献类型：
--
作者：
Liu Y;Ma C;Zhang N
组织常驻记忆T细胞（TRM）已成为T细胞生物学的一个重要组成部分。最近的研究极大地促进了我们对trm的理解。已经发现了一些共同的特征来区分存在于各种粘膜和非粘膜组织中的记忆T细胞与它们的循环对应物。由于大多数器官和组织具有独特的微环境，局部信号诱导的组织特异性特征与trm的分化、稳态和保护功能密切相关。我们将讨论TRM领域的最新进展，特别强调在个体组织环境下局部信号与TRM细胞之间的相互作用。
Tissue-resident memory T (TRM) cells have emerged to be a major component of T cell biology. Recent investigations have greatly advanced our understanding of TRMs. Common features have been discovered to distinguish memory T cells residing in various mucosal and non-mucosal tissues from their circulating counterparts. Given that most organs and tissues contain unique microenvironment, local signal-induced tissue-specific features are tightly associated with the differentiation, homeostasis and protective functions of TRMs. We will discuss the recent advances in TRM field with a special emphasis on the interaction between local signals and TRM cells in the context of individual tissue environment.