Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course.
Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course.
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DOI：
10.1002/art.34659
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发表时间：
2012-12
影响因子：
--
通讯作者：
Gillespie, Emily Baechler
中科院分区：
文献类型：
--
作者：
Reed, Ann M.;Peterson, Erik;Bilgic, Hatice;Ytterberg, Steven R.;Amin, Shreyasee;Hein, Molly S.;Crowson, Cynthia S.;Ernste, Floranne;Gillespie, Emily Baechler
肌肉酶水平是青少年和成人皮肌炎（DM）疾病活动的不敏感标志物，特别是在积极治疗阶段。为了提高我们纵向监测DM疾病活动的能力，特别是在存在免疫调节剂的情况下，我们前瞻性地评估了IFN依赖性外周血基因和趋化因子签名是否可以作为成人和青少年DM疾病活动变化的敏感和响应性生物标志物。在2次研究访视期间，前瞻性收集了51例青少年和成人DM受试者的外周血和临床数据。收集疾病活动性指标、全血I型IFN基因和趋化因子评分。我们还测量了其他促炎细胞因子的血清水平，包括IL-6。青少年和成人DM总体疾病活动度的变化与治疗前I型IFN基因评分（r=0.33，p=0.023）和调整药物使用前后IFN趋化因子评分（r=0.53，p<0.001和r=0.50，p=<0.001）的变化显著正相关。肌肉和肌外VAS分量表的变化与IFN基因和趋化因子评分的变化呈正相关（p=0.002）。血清IL-6、IL-8和TNFα水平与调整药物前后的总体、肌肉和肌外VAS变化呈正相关（p<0.05）。我们的研究结果表明，即使在使用免疫抑制剂的情况下，I型IFN基因和趋化因子评分以及IL-6、IL-8和TNFα水平的变化也可作为青少年和成人DM疾病活动性变化的敏感和响应性纵向生物标志物。
Muscle enzyme levels are insensitive markers of disease activity in juvenile and adult dermatomyositis (DM), especially during the active treatment phase. To improve our ability to monitor DM disease activity longitudinally, especially in the presence of immune modulating agents, we prospectively evaluated whether IFN-dependent peripheral blood gene and chemokine signatures could serve as sensitive and responsive biomarkers for change in disease activity in adult and juvenile DM. Peripheral blood and clinical data were collected from 51 juvenile and adult DM subjects prospectively over 2 study visits. Disease activity measures, whole-blood type I IFN gene and chemokine score were collected. We also measured serum levels of other pro-inflammatory cytokines, including IL-6. Changes in juvenile and adult DM global disease activity correlated positively and significantly with changes in the type I IFN gene score before (r=0.33, p=0.023) and IFN chemokine score before and after adjustment for medication use (r=0.53, p<0.001 and r=0.50, p=<0.001). Changes in muscle and extramuscular VAS subscales positively correlated with change in IFN gene and chemokine score (p=0.002). Serum levels of IL-6, IL-8 and TNFα were positively correlated with changes in global, muscle and extra-muscular VAS before and after adjustment for medications (p<0.05). Our findings suggest that changes in type I IFN gene and chemokine scores as well as levels of IL-6, IL-8 and TNFα may serve as sensitive and responsive longitudinal biomarkers of change in disease activity in juvenile and adult DM, even in the presence of immunosuppressant use.
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影响因子：
4.7
作者：
Rider, Lisa G.;Koziol, Deloris;Giannini, Edward H.;Jain, Minal S.;Smith, Michaele R.;Whitney-Mahoney, Kristi;Feldman, Brian M.;Wright, Susan J.;Lindsley, Carol B.;Pachman, Lauren M.;Villalba, Maria L.;Lovell, Daniel J.;Bowyer, Suzanne L.;Plotz, Paul H.;Miller, Frederick W.;Hicks, Jeanne E.
通讯作者：
Hicks, Jeanne E.
影响因子：
9.9
作者：
De Bleecker, JL;De Paepe, B;Schröder, JM
通讯作者：
Schröder, JM
影响因子：
1.2
作者：
Ishii, Wataru;Matsuda, Masayuki;Ikeda, Shu-ichi
通讯作者：
Ikeda, Shu-ichi
影响因子：
5.5
作者：
Isenberg, DA;Allen, E;Miller, F
通讯作者：
Miller, F
影响因子：
--
作者：
Niewold, Timothy B.;Kariuki, Silvia N.;Morgan, Gabrielle A.;Shrestha, Sheela;Pachman, Lauren M.
通讯作者：
Pachman, Lauren M.