Opioid growth factor (OGF) inhibits the progression of human squamous cell carcinoma of the head and neck transplanted into nude mice
Opioid growth factor (OGF) inhibits the progression of human squamous cell carcinoma of the head and neck transplanted into nude mice
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DOI：
10.1016/s0304-3835(03)00341-0
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发表时间：
2003-09-25
期刊：
影响因子：
9.7
通讯作者：
Zagon, IS
中科院分区：
文献类型：
--
作者：
McLaughlin, PJ;Levin, RJ;Zagon, IS
阿片生长因子(OGF)与OGF受体(OGFr)相互作用，是一种天然的抑制性生长因子。OGF和OGFr存在于头颈部鳞状细胞癌(SCCHN)中，OGF在组织培养中抑制SCCHN的复制。在这项研究中，接受OGF治疗的裸鼠移植了SCCHN，与对照组相比，肿瘤出现延迟，肿瘤体积缩小。OGF活性是由受体介导的。强大的阿片拮抗剂纳曲酮阻断阿片受体，刺激肿瘤形成过程。免疫组织化学方法检测到OGF和OGFr在肿瘤组织中均有表达，并通过受体结合分析对OGFr进行了表征。这些结果表明，OGF-OGFr轴在体内发挥作用，OGF是一种结构性活性分子，OGF对SCCHN的调控可能具有临床应用价值。(C)2003爱思唯尔爱尔兰有限公司。保留所有权利。
Opioid growth factor (OGF) interacts with the OGF receptor (OGFr) and serves as a native inhibitory growth factor. OGF and OGFr are present in squamous cell carcinoma of the head and neck (SCCHN), and OGF represses the replication of SCCHN in tissue culture. In this study, OGF-treated nude mice with xenografts of SCCHN displayed delays in tumor appearance and had reduced tumor size compared to controls. OGF activity was receptor-mediated. Opioid-receptor blockade by the potent opioid antagonist, naltrexone, stimulated tumorigenic processes. Both OGF and OGFr were detected in the tumors by immunohistochemistry, and OGFr was characterized by receptor binding, analysis. These results indicate that the OGF-OGFr axis functions in vivo, OGF is a Constitutively active molecule, and OGF modulation of SCCHN may have clinical application. (C) 2003 Elsevier Ireland Ltd. All rights reserved.