Effect of the antiplatelet agents ticlopidine and dipyridamole on nephrotoxic serum nephritis in rats.
Effect of the antiplatelet agents ticlopidine and dipyridamole on nephrotoxic serum nephritis in rats.
复制标题
抗血小板药物噻氯匹定和双嘧达莫对大鼠肾毒性血清肾炎的影响。
作者：
K. Izumino;H. Iida;M. Asaka;S. Sasayama
在大鼠中评估了抗血小板药物噻氯匹定和双嘧达莫对肾毒性血清肾炎（NTN）的作用。在注射兔抗大鼠肾毒性血清前7天，用兔IgG预免疫诱导加速形式的NTN。 12 只动物每天口服 20 mg 噻氯匹定，12 只动物每天两次口服 10 mg 双嘧达莫，持续 7 天。结果表明，噻氯匹定和双嘧达莫均能够显着减少尿蛋白排泄。然而，治疗动物和未治疗对照之间的肾小球变化没有显着差异。研究发现噻氯匹定和双嘧达莫可以抑制加速 NTN 中蛋白尿的发生。虽然双嘧达莫在体内的抗聚集作用相对较弱，但本研究发现双嘧达莫对蛋白质排泄相当有效。这些结果支持血小板在肾小球肾炎蛋白尿发展中的重要作用，并且表明双嘧达莫除了抑制血小板聚集之外还可能具有抗蛋白尿作用。
The effect of the antiplatelet agents, ticlopidine and dipyridamole, on nephrotoxic serum nephritis (NTN) was evaluated in rats. An accelerated form of NTN was induced with preimmunization of rabbit IgG 7 days before injection of rabbit antirat nephrotoxic serum. Twelve animals received a peroral dose of 20 mg of ticlopidine daily, and 12 animals received a peroral dose of 10 mg of dipyridamole twice daily for 7 days. It was shown that both ticlopidine and dipyridamole were able to significantly reduce urinary protein excretion. There was, however, no significant difference in glomerular changes between treated animals and nontreated controls. Ticlopidine and dipyridamole were found to suppress the development of proteinuria in accelerated NTN. Although the antiaggregative action of dipyridamole was relatively weak in vivo, dipyridamole was found to be rather effective on protein excretion in the present study. These results support the significant role of platelets in the development of proteinuria in glomerulonephritis, and it is suggested that dipyridamole may have an antiproteinuric effect other than inhibition of platelet aggregation.