Mupirocin F: structure elucidation, synthesis and rearrangements
Mupirocin F: structure elucidation, synthesis and rearrangements
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DOI：
10.1016/j.tet.2011.05.021
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发表时间：
2011-07-08
期刊：
影响因子：
2.1
通讯作者：
Willis, Christine L.
中科院分区：
文献类型：
--
作者：
Scott, Robert W.;Murphy, Annabel C.;Willis, Christine L.
利用光谱学方法对荧光假单胞菌mupF突变体提取物中的两种新代谢产物莫匹罗星F和F2的结构进行了鉴定。通过选择性氧化7-羟基，从假单胞菌酸甲酯A三醇合成莫匹罗星F甲酯，从而牢固地建立了天然产物的结构。密集的官能化骨架的重排导致不寻常的双环和三环产品。(C)2011爱思唯尔有限公司保留所有权利。
The structures of two novel metabolites, mupirocins F and F2, from extracts of the mupF mutant of Pseudomonas fluorescens were elucidated by spectroscopic methods. Methyl mupirocin F was synthesised from the triol methyl pseudomonate A by selective oxidation of the 7-hydroxyl group thus firmly establishing the structure of the natural product. Rearrangement of the densely functionalised skeleton led to unusual bicyclic and tricyclic products. (C) 2011 Elsevier Ltd. All rights reserved.