Women with low iron stores absorb iron from soybeans
Women with low iron stores absorb iron from soybeans
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DOI：
10.1093/ajcn/77.1.180
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发表时间：
2003-01-01
影响因子：
7.1
通讯作者：
Beard, JL
中科院分区：
文献类型：
--
作者：
Murray-Kolb, LE;Welch, R;Beard, JL
背景：全世界 30% 的人口（其中较大比例是妇女和儿童）缺铁。大豆是许多人类饮食中非血红素铁的主要来源，但有关铁生物利用度的信息仍然存在争议。由于大部分大豆铁存在于铁蛋白中（与谷物中因膳食中的钙、Fe(III)、植酸盐和蛋白质之间的相互作用而产生的生物利用度较差的铁不同），因此大豆提供了操纵种子铁成分以提高铁生物利用度的目标。目的：目的是重新评估大豆铁的生物利用度。设计：18 名女性，其中大多数患有边缘缺铁症，食用含有内在标记 (Fe-55) 大豆的膳食（水培生长且非结瘤）作为汤 (n = 11) 或松饼 (n = 7) 以及参考剂量的 Fe-59 作为抗坏血酸溶液中的硫酸亚铁。 14天和28天后测量红细胞中的放射性。结果：汤或松饼中Fe-55的平均吸收率为27%，参考剂量的Fe-55平均吸收率为61%。 Fe-55 在蛋白质 (49.3 +/- 3.0%) 和植酸盐之间的分布大致相等，这与可能由生长介质中高磷酸盐含量引起的结瘤大豆形成鲜明对比。红细胞放射性和血清铁蛋白浓度之间存在预期的负相关（r = -0.793，P < 0.001）。结论：这些结果表明，大豆似乎是轻度缺铁个体的营养铁的良好来源。需要对植物结瘤对大豆铁形式的影响进行更多研究，旨在提高生物利用度，以应对高危人群的铁缺乏症。
Background: Worldwide, 30% of the population, a greater proportion of whom are women and children, is iron deficient. Soybeans are a major source of nonheme iron in many human diets, but information on iron bioavailability is still conflicting. Because much of soybean iron is in ferritin [distinct from the poorly bioavailable iron in cereals resulting from interactions between calcium, Fe(III), phytate, and proteins in the meal], soybeans provide a target for manipulating seed iron composition to achieve increased iron bioavailability.Objective: The aim was to reevaluate soybean iron bioavailability.Design: Eighteen women, most with marginal iron deficiency, consumed meals with intrinsically labeled (Fe-55) soybeans (hydroponically grown and nonnodulating) as soup (n = 11) or muffins (n = 7) and a reference dose of Fe-59 as ferrous sulfate in ascorbate solution. The radioactivity in red cells was measured 14 and 28 d later.Results: The mean Fe-55 absorption from either soup or muffins was 27% and that from the reference dose was 61%. Fe-55 was distributed approximately equally between protein (49.3 +/- 3.0%) and phytate, a contrast with nodulating soybeans likely caused by a high phosphate content in the growth medium. There was an expected inverse correlation (r = -0.793, P < 0.001) between red cell radioactivity and serum ferritin concentration.Conclusions: These results show that soybeans appear to be a good source of nutritional iron in marginally iron-deficient individuals. More study is needed on the effect of plant nodulation on the form of soybean iron, aimed at enhancing bioavailability to combat iron deficiency in at-risk populations.