Correlation between type 2 diabetes, dry eye and Meibomian glands dysfunction
Correlation between type 2 diabetes, dry eye and Meibomian glands dysfunction
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DOI：
10.1016/j.optom.2019.02.003
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发表时间：
2019-10-01
影响因子：
2.3
通讯作者：
Andres, Gene-Sampedro
中科院分区：
文献类型：
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作者：
Sandra Johanna, Garzon P.;Antonio, Lopez-Alemany;Andres, Gene-Sampedro
目的：目的：探讨2型糖尿病患者睑板腺、眼表及泪液功能的变化，并探讨其相关性。方法：前瞻性研究76例男性，37例2型糖尿病患者，平均病程7 ± 5年，对照组36例。在完成眼表疾病指数（OSDI）问卷调查后，使用干涉测量系统和泪液半月板高度/TMH测量非侵入性泪膜破裂时间（NIBUT）和泪液脂质层模式。用丽丝胺绿色染色研究眼表面，用马克思线（眼睑边缘异常）评价腺体形态;表达睑板腺分泌物，并评估其质量。结果进行了分析，使用统计Kruskal-Wallis和Mann-Whitney，和相关性的斯皮尔曼Rho.Results：平均年龄为59 +/- 8岁，71%的参与者提出MGD（76%糖尿病患者和67%对照）。糖尿病组的OSDI显著较高（p = 0.01）。在MGD中，Hb 1Ac和OSDI之间存在正相关性（p = 0.0005），Hb 1Ac和OSDI之间存在强相关性。对照组NIBUT（2.47 ± 1.2 s）低于糖尿病组（2.9 ± 1.2 s），与MG炎症呈显著负相关（52.22%）。结论：2型糖尿病患者MGD较非糖尿病患者严重。糖尿病持续时间较长与MG的主要症状和变化相关。糖尿病组眼睑和泪液功能改变明显，是蒸发性干眼的主要原因，与MG炎症和阻塞高度相关。(C)2019年西班牙验光总理事会。由Elsevier Espana出版，S.L.U.
Purpose: To assess the Meibomian glands, ocular surface and tear function in patients with type 2 diabetes, and study the correlation between these conditions.Methods: Prospective study of 76 males, 37 with type 2 diabetes with an average of duration between 7 +/- 5 years, and 36 males from control group. After completing an ocular surface disease index (OSDI) questionnaire, the non-invasive tear film break-up time (NIBUT) and the tear lipid layer pattern was performed using interferometry system and tear meniscus height/TMH. Ocular surface was studied with lissamine green staining and morphology of the glands with evaluation of Marx's line (lid margin abnormalities); meibomian secretion was expressed and was also assessed the quality. The results were analyzed using the statistical Kruskal-Wallis and Mann-Whitney, and correlations by Spearman Rho.Results: The mean age was 59 +/- 8 years; 71% of participants presented MGD (76% diabetics and 67% controls). OSDI were significantly higher (p = 0.01) in the diabetic group. A positive correlation was found between glycemia and symptoms (p = 0.0005) and strong correlation between Hb1Ac and OSDI in MGD. NIBUT was lower in the control group (2.47 +/- 1.2 s) than for the diabetic group (2.9 +/- 1.2 s), with a significant inverse correlation (52.22%) with MG inflammation.Conclusions: MGD in type 2 diabetic patients is more severe compared with nondiabetic patients. Longer duration of diabetes is associated with major symptoms and changes in MG. Diabetic group showed major changes in lids and tear function, accounting for evaporative dry eye and presenting a high degree of correlation with MG inflammation and obstruction. (C) 2019 Spanish General Council of Optometry. Published by Elsevier Espana, S.L.U.