Priorities among HIV-positive individuals for tuberculosis preventive therapies.
Priorities among HIV-positive individuals for tuberculosis preventive therapies.
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DOI：
10.5588/ijtld.18.0740
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发表时间：
2020-04-01
期刊：
影响因子：
--
通讯作者：
Bridges JFP
中科院分区：
文献类型：
--
作者：
Kim HY;Hanrahan CF;Dowdy DW;Martinson NA;Golub JE;Bridges JFP
异烟肼预防治疗（IPT）在艾滋病毒感染者（PLWH）中的应用进展缓慢。我们调查了南非14个初级卫生诊所中最近被诊断感染艾滋病毒的成年人。通过文献回顾和质性访谈，选择了16个与PLWH预防治疗相关的潜在障碍和促进因素。使用最佳-最差缩放（BWS）来量化属性的相对重要性。BWS分数是根据参与者在六个选项中（跨多个选择集）选择每个属性为最佳或最差的频率来计算的，并从0（总是被选为最差）重新调整为100（总是被选为最好），并与当前是否接受IPT进行比较。在调查的342例患者中，33% （n=114）的患者目前正在服用IPT。与未感染艾滋病毒的人拥有相同的生活标准是最重要的（BWS评分=67.3，SE=0.6），其次是对医疗保健提供者的信任（评分=66.3±0.6）。公立诊所的护理标准差（评分=30.6±0.6）和药物副作用（评分=33.7±0.6）是最不重要的。IPT状态的BWS分数在一些属性上有所不同，但总体排名相似（spearman的rho=0.9）。PLWH患者对预防治疗的获益感较高。应鼓励卫生保健提供者开具IPT处方，以提高PLWH对IPT的吸收。
The uptake of isoniazid preventive therapy (IPT) has been slow among people living with HIV (PLWH). We surveyed adults recently diagnosed with HIV in 14 South African primary health clinics. Sixteen potential barriers and facilitators related to preventive therapy among PLWH were selected based on the literature review and qualitative interviews. Best-worst scaling (BWS) was used to quantify the relative importance of the attributes. BWS scores were calculated based on the frequency of participants’ selecting each attribute as the best or worst among six options (across multiple choice sets) and rescaled from 0 (always selected as worst) to 100 (always selected as best) and compared by currently receiving IPT or not. Among 342 patients surveyed, 33% (n=114) were currently taking IPT. Having the same standard of life as someone without HIV was most highly prioritized (BWS score=67.3, SE=0.6), followed by trust in healthcare providers (score=66.3±0.6). Poor standard of care in public clinics (score=30.6±0.6) and side effects of medications (score=33.7±0.6) were least prioritized. BWS scores differed by IPT status for few attributes, but overall ranking was similar (spearman’s rho=0.9). Perceived benefits of preventive therapy were high among PLWH. IPT prescription by healthcare providers should be encouraged to enhance IPT uptake among PLWH.
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影响因子：
2.4
作者：
Ostermann J;Brown DS;Mühlbacher A;Njau B;Thielman N
通讯作者：
Thielman N
影响因子：
4.1
作者：
Lawn SD;Churchyard G
通讯作者：
Churchyard G
DOI：
10.1080/09540121.2017.1283390
发表时间：
2017-01-01
影响因子：
1.7
作者：
Jacobson, Karen B.;Niccolai, Linda;Shenoi, Sheela V.
通讯作者：
Shenoi, Sheela V.
影响因子：
2.8
作者：
Kerrigan, Deanna;Tudor, Carrie;Golub, Jonathan E.
通讯作者：
Golub, Jonathan E.
影响因子：
1.2
作者：
Mindachew, Mesele;Deribew, Amare;Biadgilign, Sibhatu
通讯作者：
Biadgilign, Sibhatu