Ghrelin family of peptides and gut motility
Ghrelin family of peptides and gut motility
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DOI：
10.1111/j.1440-1746.2011.06638.x
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发表时间：
2011-04-01
影响因子：
4.1
通讯作者：
Inui, Akio
中科院分区：
文献类型：
--
作者：
Asakawa, Akihiro;Ataka, Koji;Inui, Akio
酰基Ghrelin、去酰基Ghrelin和Obestatin是从胃肠道分离出来的三种多肽，由相同的前Proghrelin基因编码。三种Ghrelin基因产物参与调节食欲、脂肪生成、葡萄糖代谢、细胞增殖、免疫、睡眠、记忆、焦虑、认知和压力。用测压法观察了Ghrelin家族多肽对清醒自由活动大鼠胃和十二指肠运动功能的影响。侧脑室(Icv)和静脉(Iv)注射酰基生长激素(Acyl Ghrelin)可引起喂养大鼠十二指肠空腹运动。侧脑室和静脉注射Des-acyl ghrelin可扰乱胃窦的空腹运动活动。侧脑室注射促肾上腺皮质激素释放因子(CRF)2受体拮抗剂可拮抗静脉注射去酰基Ghrelin引起的胃运动改变。静脉注射他汀可降低喂养大鼠十二指肠胃窦运动指数百分比，延长十二指肠恢复禁食运动所需时间。侧脑室注射CRF-1和CRF-2受体拮抗剂可阻断奥贝他汀对胃十二指肠运动的影响。Ghrelin基因产物调节与摄食相关的胃十二指肠运动。胃可能通过作为内分泌器官的酰基Ghrelin、去酰基Ghrelin和奥贝他汀调节胃肠运动等多种功能。越来越多地了解Ghrelin家族多肽对胃肠动力的影响，可能会导致功能性胃肠疾病的创新治疗。
Acyl ghrelin, des-acyl ghrelin, and obestatin are three peptides isolated from the gastrointestinal tract and encoded by the same preproghrelin gene. Three ghrelin gene products participate in modulating appetite, adipogenesis, glucose metabolism, cell proliferation, immune, sleep, memory, anxiety, cognition, and stress. We have investigated the effects of ghrelin family of peptides on fed and fasted motor activities in the stomach and duodenum of freely moving conscious rats by manometric method. Intracerebroventricular (ICV) and intravenous (IV) administration of acyl ghrelin induced fasted motor activity in the duodenum in fed rats. ICV and IV administration of des-acyl ghrelin disrupted fasted motor activity in the antrum. Changes in gastric motility induced by IV administration of des-acyl ghrelin were antagonized by ICV administration of a corticotropin-releasing factor (CRF) 2 receptor antagonist. IV administration of obestatin decreased the percentage motor index in the antrum and prolonged the time taken to return to fasted motility in the duodenum in fed rats. ICV administration of CRF 1 and 2 receptor antagonists prevented the effects of obestatin on gastroduodenal motility. Ghrelin gene products regulate feeding-associated gastroduodenal motility. Stomach may regulate various functions including gastrointestinal motility via acyl ghrelin, des-acyl ghrelin and obestatin as an endocrine organ. Increasing knowledge of the effects of ghrelin family of peptides on gastrointestinal motility could lead to innovative new therapies for functional gastrointestinal disorders.