DISSOCIATION BETWEEN THE EFFECTS OF BENZODIAZEPINE RECEPTOR AGONISTS ON BEHAVIORAL VIGILANCE AND RESPONSIVITY
DISSOCIATION BETWEEN THE EFFECTS OF BENZODIAZEPINE RECEPTOR AGONISTS ON BEHAVIORAL VIGILANCE AND RESPONSIVITY
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DOI：
10.1007/bf02245501
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发表时间：
1992-10-01
影响因子：
3.4
通讯作者：
SARTER, M
中科院分区：
文献类型：
--
作者：
DUDCHENKO, P;PAUL, B;SARTER, M
在简单反应时间模式下，研究了苯二氮卓受体（BZR）完全激动剂氯二氮吡酯和咪达唑仑，以及部分激动剂-卡波林zk91 296对大鼠表现的影响。这项任务要求动物对一个罕见且不可预测的短暂（50毫秒）视觉刺激做出反应。从信号检测理论得出的信号敏感性和反应偏差的非参数测量被用作分离这些药物对注意能力和一般反应的影响的基础。咪达唑仑（0.1 ~ 3.13 mg/kg）对信号敏感性和一般反应性的剂量依赖性作用是平行发生的。相比之下，氯二氮环氧化物（1.56 ~ 12.5 mg/kg）对信号敏感性的影响在很大程度上独立于对反应偏倚的影响。部分激动剂zk91 296 （0.39 ~ 25 mg/kg）对生产性能影响不大。最高剂量氯二氮环氧酯和咪达唑仑的作用被BZR拮抗剂Ro15-1788 （15 mg/kg）联合施用逆转。此外，刺激呈现时间延长至500 ms时，氯二氮环氧化物对信号敏感性的影响程度降低。这些结果支持了BZR激动剂引起的注意力能力的破坏不一定与对一般反应性或镇静的影响相混淆的假设，因此可能代表了BZR激动剂的独立药理学性质。
The effects of benzodiazepine receptor (BZR) full agonists chlordiazepoxide and midazolam, and the partial agonist beta-carboline ZK 91 296 on the rat's performance in a simple reaction time paradigm were examined. This task required the animals to respond to a rarely and unpredictably occuring brief (50 ms) visual stimulus. Non-parametric measures of signal sensitivity and response bias derived from signal-detection theory were used as a basis for the dissociation between the effects of these drugs on attentional abilities and general responsivity. The dose-dependent effects of midazolam (0.1-3.13 mg/kg) on signal sensitivity and general responsivity occurred in parallel. In contrast, the effects of chlordiazepoxide (1.56-12.5 mg/kg) on signal sensitivity were largely independent from effects on response bias. The partial agonist ZK 91 296 (0.39-25 mg/kg) in general had little effect on performance. The effects of the highest doses of chlordiazepoxide and midazolam were reversed by the co-administration of the BZR antagonist Ro15-1788 (15 mg/kg). Additionally, extension of the stimulus presentation time to 500 ms decreased the magnitude of the effect of chlordiazepoxide on signal sensitivity. These results support the hypothesis that BZR agonist-induced disruption of attentional abilities is not necessarily confounded by effects on general responsivity or sedation, and thus may represent a discrete pharmacological property of BZR-agonists.