MUC16 in non-small cell lung cancer patients affected by familial lung cancer and indoor air pollution: clinical characteristics and cell behaviors
MUC16 in non-small cell lung cancer patients affected by familial lung cancer and indoor air pollution: clinical characteristics and cell behaviors
复制标题
受家族性肺癌和室内空气污染影响的非小细胞肺癌患者中MUC16：临床特征和细胞行为
DOI：
10.21037/tlcr.2019.07.10
复制
发表时间：
2019-08-01
影响因子：
4
通讯作者：
Ding, Xiaojie
中科院分区：
文献类型：
--
作者：
Chen, Ying;Huang, Yunchao;Ding, Xiaojie
Background: Inherited susceptibility and environmental carcinogens are crucial players in lung cancer etiology, and both exhibit population heterogeneity. MUC16 is overexpressed in various cancers and often associated with poor prognosis. Present work was to investigate the clinical significance of MUC16 in non-small cell lung cancer patients affected by familial lung cancer (FLC) and indoor air pollution caused by coal use.Methods: Clinicopathologic characteristics and MUC16 expression were analyzed and evaluated in our subject population. Vectors were constructed for MUC16 gene knockout and overexpression, then we examined how MUC16 affected lung cancer cell behaviors, including proliferation, migration, invasion and chemoresistance.Results: FLC showed significant association with early-onset (P
