Effect of posttransplantation administration of peripheral blood lymphocytes in skin-grafted mice treated with antilymphocyte serum or antilymphocyte serum plus bone marrow.
Effect of posttransplantation administration of peripheral blood lymphocytes in skin-grafted mice treated with antilymphocyte serum or antilymphocyte serum plus bone marrow.
复制标题
移植后给予抗淋巴细胞血清或抗淋巴细胞血清加骨髓处理的植皮小鼠外周血淋巴细胞的影响。
DOI：
10.1097/00007890-198707000-00016
复制
发表时间：
1987
期刊：
影响因子：
6.2
通讯作者：
Gozzo,JJ
中科院分区：
文献类型：
--
作者：
DeFazio,SR;Hartner,WC;Monaco,AP;Gozzo,JJ
Posttransplantation administration of donor-specific bone marrow cells to ALS-treated allograft recipients produces graft survival that is greater than that produced by ALS treatment alone. We have now studied the effect of peripheral blood lymphocytes (PBLs) in a mouse skin allograft model using this protocol (C3H skin grafted to B6AF 1 mice, day 0; ip ALS on days—1 and+ 2; iv bone marrow days+ 6 or+ 7). When PBLs are injected in place of bone marrow cells, graft survival is extended beyond that noted for control mice given ALS only. The timing and specificity of this phemonenon suggest that it resembles the effect produced by post-transplant bone marrow administration and not that associated with pretransplant blood transfusion. The PBLs active in graft prolongation are Thy-1-negative and display a density in Percoll gradients similar to that of the active marrow cells.
