Gelfoam as a barrier to prevent polymethylmethacrylate-induced thermal injury of the spinal cord: in vitro and in vivo studies in pigs.
Gelfoam as a barrier to prevent polymethylmethacrylate-induced thermal injury of the spinal cord: in vitro and in vivo studies in pigs.
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DOI：
10.1097/00002517-199912000-00009
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发表时间：
1999-12
期刊：
影响因子：
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通讯作者：
C. Park;M. Allen;J. Schoonmaker;P. Yuan;B. Bai;H. Yuan
中科院分区：
文献类型：
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作者：
C. Park;M. Allen;J. Schoonmaker;P. Yuan;B. Bai;H. Yuan
明胶海绵(明胶海绵；Upjohn，卡拉马祖，密苏里州，美国)在用聚甲基丙烯酸甲酯骨水泥重建椎体时，常用作保护脊髓免受热损伤的介入性屏障。本研究的目的是记录在聚甲基丙烯酸甲酯重建椎体切除缺损区时硬膜外和硬膜内的温度。在猪的体内和体外模型中，比较了三种手术方法(次全椎体切除加明胶海绵屏障和无屏障全椎体切除)。正如预期的那样，在体内(52.8摄氏度)和体外(58+/-2摄氏度)，在没有明胶海绵屏障的情况下，全椎体切除缺损处产生了最高的硬膜外温度。明胶海绵屏障提供了一些防止热传递的保护，但峰值温度和绝对温度升高显著高于后部皮质完整的缺损组(p<；0.05)。这些结果表明，完整的后皮质对热传递提供了最好的保护，而使用明胶海绵屏障似乎只对热损伤提供了部分保护。
Gelatin sponge (Gelfoam; Upjohn, Kalamazoo, MI, U.S.A.) is commonly used as an interpositional barrier to shield the spinal cord from thermal injury during vertebral reconstruction with polymethylmethacrylate bone cement. The aim of this study was to record epidural and intradural temperatures during polymethylmethacrylate reconstruction of vertebral corpectomy defects. Three surgical techniques (subtotal corpectomy, total corpectomy with insertion of a Gelfoam barrier, and total corpectomy with no barrier) were compared in vivo and in vitro in a porcine model. As expected, total corpectomy defects cemented without a Gelfoam barrier produced the highest epidural temperatures in vivo (52.8 degrees C) and in vitro (58 +/- 2 degrees C). The Gelfoam barrier provided some protection against heat transfer, but peak temperatures and absolute temperature increases were significantly higher than in defects with an intact posterior cortex (p < 0.05). These results indicate that an intact posterior cortex provides the best protection against heat transfer, whereas the use of a Gelfoam barrier appears to provide only partial protection against thermal injury.