Determinants of participation in glaucoma genomic research in South East Nigeria: A cross-sectional analytical study.
Determinants of participation in glaucoma genomic research in South East Nigeria: A cross-sectional analytical study.
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DOI：
10.1371/journal.pone.0289643
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
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作者：
基因组研究促进了对人类健康和疾病的理解。它还推动了显著遗传关联的发现(S)以及有针对性的筛查、诊断和治疗战略。人类主体的参与对基因组研究的成功至关重要。这是一项在尼日利亚东南部埃努古的两个三级中心进行的横断面分析研究。对符合条件的同意参与者进行了半结构化问卷调查。获得了有关他们的人口统计数据、参与基因组研究的意愿和参与动机的数据。使用STATA版本17对数据进行分析，并使用中位数、频率和四分位数范围(IQR)进行汇总。协变量之间的相关性用卡方检验和多变量Logistic回归进行评估。在228例青光眼患者中，119例(52.2%)为女性，109例(47.8%)为男性。年龄中位数为(智商=50-76)。尽管219名参与者(96.0%)表示愿意参与青光眼遗传学研究，但如果没有结果反馈给参与者，只有27名参与者(11.9%)愿意参与(χ2=18.59P<；0.001)。没有参与者表示愿意提交眼组织样本。如果预期的研究需要在死后提交身体样本，大多数(96.2%)受试者将不会参与。想要更多地了解青光眼(63%)是参与调查的最常见原因。在多变量Logistic模型中，与41-60岁的受试者相比，61-90岁的受试者(p=0.004，OR=7.2后)表示愿意参与青光眼遗传学研究的可能性是41-60岁受试者的7倍。其他协变量并不影响参与者的意愿。青光眼受试者更有可能参与基因研究，如果他们会收到结果的反馈。参与基因研究的意愿与年龄显著相关。在我们的研究中，我们没有对结果反馈给参与者的显著选项进行评估。
Genomic research advances the understanding of human health and disease. It also drives both the discovery of salient genetic association(s) as well as targeted screening, diagnostic and therapeutic strategies. Human subject participation is crucial for the success of genomic research. This is a cross sectional analytical study conducted at two tertiary centers in Enugu Southeast Nigeria. Semi structured questionnaires were administered to eligible consenting participants. Data on their demographics, willingness to participate in genomic research and motivation for participation were obtained. Data was analyzed using Stata version 17 and summarized using median, frequencies and interquartile range(IQR). Associations between covariates were evaluated with Chi square test and multivariable logistic regression. Among 228 glaucoma subjects who participated in our study,119(52.2%) were female and 109(47.8%) were male. The median age was 64 years(IQR = 50–76). Although 219 (96.0%) participants expressed willingness to participate in a glaucoma genetic study, only 27(11.9%) of them will be willing to participate if there will not be feedback of results to participants (χ2 = 18.59, P<0.001). No participant expressed willingness to submit ocular tissue samples. Majority (96.2%) of subjects will not participate if the intended research required submission of body samples after death. Desire to know more about glaucoma (63%) was the most common reason for participation. In a multivariable logistic model, subjects between 61–90 years (p = 0.004, OR = 7.2) were 7 times more likely to express willingness to participate in glaucoma genetic research after adjusting for other covariates when compared to subjects aged 41–60 years. Other covariates did not influence participants’ willingness. Glaucoma subjects are more likely to be willing to participate in genetic research, if they would receive feedback of results. Willingness to participate in genetic research is significantly associated with age. We did not evaluate the salient options for feedback of results to participants in our study.
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影响因子：
64.8
作者：
Gurdasani, Deepti;Carstensen, Tommy;Tekola-Ayele, Fasil;Pagani, Luca;Tachmazidou, Ioanna;Hatzikotoulas, Konstantinos;Karthikeyan, Savita;Iles, Louise;Pollard, Martin O.;Choudhury, Ananyo;Ritchie, GrahamR. S.;Xue, Yali;Asimit, Jennifer;Nsubuga, Rebecca N.;Young, Elizabeth H.;Pomilla, Cristina;Kivinen, Katja;Rockett, Kirk;Kamali, Anatoli;Doumatey, Ayo P.;Asiki, Gershim;Seeley, Janet;Sisay-Joof, Fatoumatta;Jallow, Muminatou;Tollman, Stephen;Mekonnen, Ephrem;Ekong, Rosemary;Oljira, Tamiru;Bradman, Neil;Bojang, Kalifa;Ramsay, Michele;Adeyemo, Adebowale;Bekele, Endashaw;Motala, Ayesha;Norris, Shane A.;Pirie, Fraser;Kaleebu, Pontiano;Kwiatkowski, Dominic;Tyler-Smith, Chris;Rotimi, Charles;Zeggini, Eleftheria;Sandhu, Manjinder S.
通讯作者：
Sandhu, Manjinder S.
影响因子：
4.6
作者：
Williams SE;Carmichael TR;Allingham RR;Hauser M;Ramsay M
通讯作者：
Ramsay M
影响因子：
9.8
作者：
Retshabile, Gaone;Mlotshwa, Busisiwe C.;Hanchard, Neil A.
通讯作者：
Hanchard, Neil A.
DOI：
10.1177/15562646211043985
发表时间：
2021-12
期刊：
Journal of empirical research on human research ethics : JERHRE
影响因子：
--
作者：
Ralefala D;Kasule M;Matshabane OP;Wonkam A;Matshaba M;de Vries J
通讯作者：
de Vries J
影响因子：
3.7
作者：
Cuccaro, Michael L.;Manrique, Clara P.;McCauley, Jacob L.
通讯作者：
McCauley, Jacob L.