Body mass index as a prognostic factor in patients with extranodal natural killer/T-cell lymphoma, nasal type.
Body mass index as a prognostic factor in patients with extranodal natural killer/T-cell lymphoma, nasal type.
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体重指数作为鼻型结外自然杀伤/T细胞淋巴瘤患者的预后因素
DOI：
10.18632/oncotarget.11373
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发表时间：
2016-11-22
期刊：
影响因子：
--
通讯作者：
Jiang Y
中科院分区：
文献类型：
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作者：
Liu J;Deng YT;Zhang L;Li N;Jiang M;Zou LQ;Jiang Y
流行病学证据表明，体重指数 (BMI) 可以预测多种癌症的生存率。然而，BMI 在鼻型结外自然杀伤/T 细胞淋巴瘤 (ENKTL) 中的作用仍不清楚。这项回顾性单中心研究纳入了 251 名新诊断患者，以确定 BMI 对 ENKTL 的预后价值。其中，203 名患者接受了放化疗，37 名患者接受了单纯化疗，8 名患者接受了单纯放疗，3 名患者仅接受了最佳支持治疗。中位随访时间为 28 个月，预计 3 年总生存率 (OS) 和无进展生存率 (PFS) 分别为 64.4% 和 60.9%。接受者操作特征曲线显示 20.8 kg/m2 是预测生存的最佳 BMI 截止值。 BMI < 20.8 kg/m2 与较低的 3 年 OS（52.8% vs. 72.9%，P = 0.001）和 PFS（48.8% vs. 69.8%，P < 0.001）率相关。多变量分析表明，BMI、体能状态、乳酸脱氢酶（LDH）水平、化疗和放疗是 OS 的独立预后因素。此外，BMI、结外部位数量、体力状态、LDH 和放疗可预测 PFS。这些结果表明 20.8 kg/m2 临界值的 BMI 可能是 ENKTL 患者的一个预后因素。
Epidemiological evidence has shown that body mass index (BMI) can predict survival in several types of cancer. However, the role of BMI in extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is still unclear. This retrospective single-center study included 251 newly diagnosed patients to determine the prognostic value of BMI in ENKTL. Of these, 203 patients received chemoradiotherapy, 37 received chemotherapy alone, 8 received radiotherapy alone, and 3 received only best supportive care. With a median follow-up of 28 months, the estimated 3-year overall survival (OS) and progression-free survival (PFS) rates were 64.4% and 60.9%, respectively. The receiver-operating characteristic curve showed that 20.8 kg/m2 was the optimal cut-off of BMI to predict survival. BMI < 20.8 kg/m2 was associated with lower 3-year OS (52.8% vs. 72.9%, P = 0.001) and PFS (48.8% vs. 69.8%, P < 0.001) rates. Multivariate analysis indicated that BMI, performance status, lactate dehydrogenase (LDH) levels, chemotherapy, and radiotherapy were independent prognostic factors for OS. Furthermore, BMI, number of extranodal sites, performance status, LDH, and radiotherapy were predictive of PFS. These results suggest that BMI at the cut-off of 20.8 kg/m2 might be a prognostic factor in patients with ENKTL.