Mammary radioiodine accumulation due to functional sodium iodide symporter expression in a benign fibroadenoma
Mammary radioiodine accumulation due to functional sodium iodide symporter expression in a benign fibroadenoma
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DOI：
10.1016/j.bbrc.2006.08.170
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发表时间：
2006-11-03
影响因子：
3.1
通讯作者：
Spitzweg, C.
中科院分区：
文献类型：
--
作者：
Berger, F.;Unterholzner, S.;Spitzweg, C.
碘化钠同向转运体（NIS）不仅在甲状腺中介导碘化物的主动转运，而且在各种非甲状腺组织中介导碘化物的主动转运，包括哺乳期乳腺和大多数乳腺癌，从而为放射性碘在乳腺癌中的诊断和治疗应用提供了可能性。在本报告中，我们介绍了一名 57 岁的多灶性甲状腺乳头状癌患者，在放射性碘治疗后的 I-131 扫描中，显示右乳病灶内有局灶性放射性碘积聚。 CT 和 MR 乳房 X 光检查显示右乳房有局灶性实性病变，提示纤维腺瘤，并经组织学检查证实。使用人 NIS 抗体对石蜡包埋的肿瘤组织切片进行免疫染色，证明 NIS 特异性免疫反应性仅限于乳腺导管上皮细胞。总之，在甲状腺癌患者中，我们在治疗后 I-131 扫描中发现，表达高水平功能活性 NIS 蛋白的良性乳腺纤维腺瘤是局灶性乳腺放射性碘积累的根本原因。这些数据首次表明功能性NIS表达不仅限于哺乳期乳腺和恶性乳腺组织，还可以在良性乳腺病变中检测到，例如乳腺纤维腺瘤。 (c) 2006 Elsevier Inc. 保留所有权利。
The sodium iodide symporter (NIS) has been characterized to mediate the active transport of iodide not only in the thyroid gland but also in various non-thyroidal tissues, including lactating mammary gland and the majority of breast cancers, thereby offering the possibility of diagnostic and therapeutic radioiodine application in breast cancer. In this report, we present a 57-year-old patient with multifocal papillary thyroid carcinoma, who showed focal radioiodine accumulation in a lesion in the right breast on a posttherapy I-131 scan following radioiodine therapy. CT and MR-mammography showed a focal solid lesion in the right breast suggestive of a fibroadenoma, which was confirmed by histological examination. Immunostaining of paraffin-embedded tumor tissue sections using a human NIS antibody demonstrated NIS-specific immunoreactivity confined to epithelial cells of mammary ducts. In conclusion, in a thyroid cancer patient we identified a benign fibroadenoma of the breast expressing high levels of functionally active NIS protein as underlying cause of focal mammary radioiodine accumulation on a posttherapy I-131 scan. These data show for the first time that functional NIS expression is not restricted to lactating mammary gland and malignant breast tissue, but can also be detected in benign breast lesions, such as fibro-adenomata of the breast. (c) 2006 Elsevier Inc. All rights reserved.