Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice
Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice
复制标题
DOI：
10.1038/nprot.2006.275
复制
发表时间：
2006-01-01
期刊：
影响因子：
14.8
通讯作者：
Morgan, Dave
中科院分区：
文献类型：
--
作者：
Alamed, Jennifer;Wilcock, Donna M.;Morgan, Dave
径向臂水迷宫(RAWM)包含六条游泳道(臂)，从一个开放的中心区域延伸出来，其中一条臂(目标臂)的末端有一个逃生平台。对于给定的鼠标，目标手臂位置保持不变。在第一天，小鼠被训练进行15次试验(间隔超过3小时)，试验在可见平台和隐藏平台之间交替进行。在第二天，小鼠被训练在隐藏平台上进行15次试验。进入错误的手臂被记分为错误。RAWM具有干径向臂迷宫的空间复杂性和性能测量简单性，并结合了在Morris水迷宫中观察到的快速学习和强大的动机，而不需要脚部电击或食物剥夺作为激励因素。每天两次，在两天内可以测试16只小鼠。
The radial arm water maze (RAWM) contains six swim paths (arms) extending out of an open central area, with an escape platform located at the end of one arm (the goal arm). The goal arm location remains constant for a given mouse. On day 1, mice are trained for 15 trials (spaced over 3 h), with trials alternating between visible and hidden platform. On day 2, mice are trained for 15 trials with the hidden platform. Entry into an incorrect arm is scored as an error. The RAWM has the spatial complexity and performance measurement simplicity of the dry radial arm maze combined with the rapid learning and strong motivation observed in the Morris water maze without requiring foot shock or food deprivation as motivating factors. With two sessions each day, 16 mice can be tested over 2 days.