Effects of early low-level lead exposure on human brain structure, organization and functions
Effects of early low-level lead exposure on human brain structure, organization and functions
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DOI：
10.1017/s2040174410000486
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发表时间：
2011-02-01
影响因子：
1.7
通讯作者：
Cecil, K. M.
中科院分区：
文献类型：
--
作者：
Cecil, K. M.
先进的神经成像技术为儿童铅暴露如何影响大脑提供了独特的见解。体积磁共振成像提供了关于大脑内整体、区域和亚成分结构大小的解剖学信息。扩散张量成像通过定量描述水分子如何在白质内扩散来提供有关白质结构的信息。质子磁共振波谱通过选择代谢物的浓度水平产生神经元、轴突和神经胶质元素的定量测量。功能性磁共振成像可以推断与特定任务相关的神经元活动。辛辛那提铅研究是一项相对均匀的出生队列研究，纵向监测了30多年，采用这些技术，人们可以非侵入性和定量地探索儿童铅暴露与成人大脑结构、组织和功能的关系。这些研究得出了环境铅暴露如何影响人类健康的重要发现。
Advanced neuroimaging techniques offer unique insights into how childhood lead exposure impacts the brain. Volumetric magnetic resonance imaging affords anatomical information about the size of global, regional and subcomponent structures within the brain. Diffusion tensor imaging provides information about white matter architecture by quantitatively describing how water molecules diffuse within it. Proton magnetic resonance spectroscopy generates quantitative measures of neuronal, axonal and glial elements via concentration levels of select metabolites. Functional magnetic resonance imaging infers neuronal activity associated with a given task performed. Employing these techniques in the study of the Cincinnati Lead Study, a relatively homogeneous birth cohort longitudinally monitored for over 30 years, one can non-invasively and quantitatively explore how childhood lead exposure is associated with adult brain structure, organization and function. These studies yield important findings how environmental lead exposure impacts human health.