The influence of the menstrual cycle on reactivity to a CO2 challenge among women with and without premenstrual symptoms.
The influence of the menstrual cycle on reactivity to a CO2 challenge among women with and without premenstrual symptoms.
复制标题
月经周期对有或没有经前症状的女性对二氧化碳挑战反应的影响。
DOI：
10.1080/16506073.2016.1236286
复制
发表时间：
2017
影响因子：
4.7
通讯作者：
Rasmusson,AnnM
中科院分区：
文献类型：
--
作者：
Nillni,YaelI;Pineles,SuzanneL;Rohan,KellyJ;Zvolensky,MichaelJ;Rasmusson,AnnM
在 DSM-5 中，临床上显着的经前症状 (PMS) 被概念化为抑郁症，但它可能与焦虑和恐惧相关疾病具有相同的病理生理过程。具体来说，患有经前综合症的女性在生物挑战过程中恐慌的几率更高。目前还不清楚这种内感受敏感性的增加是普遍的脆弱性还是经前阶段特有的。目前的研究调查了月经周期阶段对有（n = 11）和没有（n = 26）临床显着经前综合症（N = 37）的女性对二氧化碳挑战的反应的作用。在卵泡后期（第 6-12 天），患有和不患有 PMS 的女性对 CO2 挑战的反应相似，而在经前阶段（月经前 5 天内），患有 PMS 的女性报告的应对挑战的恐慌症状明显比没有 PMS 的女性更强烈。患有经前综合症的女性容易惊慌可能是经前阶段所特有的。讨论了这种现象背后的潜在心理和神经生物学机制。
Clinically significant premenstrual symptoms (PMS) is conceptualized as a depressive disorder in DSM-5, however, it may share pathophysiological processes with anxiety- and fear-related disorders. Specifically, women with PMS panic at higher rates during biological challenge procedures. It is unclear if this increased interoceptive sensitivity is a general vulnerability or specific to the premenstrual phase. The current study examined the role of menstrual cycle phase on reactivity to a CO2challenge among women with (n= 11) and without (n= 26) clinically significant PMS (N= 37). During the late follicular phase (days 6–12), women with and without PMS responded similarly to the CO2challenge, whereas during the premenstrual phase (within 5 days before menses), women with PMS reported significantly more intense panic symptoms in response to the challenge than women without PMS. Vulnerability to panic in women with PMS may be specific to the premenstrual phase. Potential psychological and neurobiological mechanisms underlying this phenomenon are discussed.