Long-Term Continuous Intravenous Insulin Therapy with a Portable Insulin Dosage-regulating Apparatus
Long-Term Continuous Intravenous Insulin Therapy with a Portable Insulin Dosage-regulating Apparatus
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使用便携式胰岛素剂量调节装置进行长期连续静脉注射胰岛素治疗
作者：
K. Irsigler;H. Kritz
5名糖尿病志愿者使用便携式胰岛素剂量调节仪（PIDRA），时间从1周到3个多月不等，以探索使用这种仪器在长时间内实现接近正常血糖控制的可能性。PIDRA由一个火柴盒大小的胰岛素泵和一个口袋大小的电子控制箱组成。它可以注入一个预先设定的胰岛素基础率加上外部操纵的补充剂量在矩形剖面。血糖控制质量通过Miles生物定子监测，并通过患者在门诊阶段的自我检测。在住院条件下，相对简单的PIDRA胰岛素给药方式在实现正常血糖方面几乎与bio定子一样有效，并且可以长时间保持良好的控制。与传统的皮下注射相比，该装置更容易改变胰岛素剂量，降低低血糖发作的风险。一些技术问题仍有待解决，但结论是PIDRA代表了一种可行的替代方法，作为一种实现严格控制的手段，至少是朝着植入血糖依赖型胰岛素输注系统的目标迈进了一步。
A portable insulin dosage-regulating apparatus (PIDRA) was used with five volunteer diabetic subjects for periods ranging from 1 wk to more than 3 months to explore the possibilities of achieving near normoglycemic control over long time periods with such an apparatus. PIDRA consists of a matchbox size pump with insulin reservoir and a pocket size electronic control box. It can infuse a preprogrammed basal rate of insulin plus externally manipulated supplementary doses in rectangular profiles. The quality of blood glucose control was m nitored with the Miles Biostator and through self-testing by the patient in the outpatient phases. Under inpatient conditions, the relatively simple PIDRA insulin administration profile was almost as effective in achieving normoglycemia as the Biostator, and good control could be maintained over long periods of time. The apparatus allows considerably greater ease in variation of insulin dosage with less risk of hypoglycemic episodes as compared with conventional subcutaneous injections. Several technical problems remain to be solved, but it is concluded that PIDRA represents a viable alternative as a means of achieving tight control, at least as a step toward the goal of an implanted glucose-contingent insulin infusion system.