Physical activity, anthropometric factors and risk of pancreatic cancer: Results from the Canadian Enhanced Cancer Surveillance System
Physical activity, anthropometric factors and risk of pancreatic cancer: Results from the Canadian Enhanced Cancer Surveillance System
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DOI：
10.1002/ijc.1446
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发表时间：
2001-10-01
影响因子：
6.4
通讯作者：
Mao, Y
中科院分区：
文献类型：
--
作者：
Hanley, AJG;Johnson, KC;Mao, Y
为了探索胰岛素抵抗可能是胰腺癌病因的假设，我们评估了与人体测量因素和身体活动相关的胰腺癌风险，这两者都是人类胰岛素敏感性的重要决定因素。在加拿大10个省中的7个省进行的一项基于人群的病例对照研究中，312名组织学证实的胰腺癌患者与2,919名对照患者进行了比较。参与者被要求报告他们在访谈前两年的暴露状况。体重指数最高四分位数（BMI，大于或等于28.3 kg/m(2)）的男性患胰腺癌的风险增加[校正优势比(or) = 1.90, 95%可信区间（CI） 1.08-3.35]。此外，与体重减少小于或等于2.9%（大于或等于10.2%,or = 0.51, 95% CI 0.30-0.86）的男性相比，报告体重减少至少2.9%的男性风险降低。受访前2年的BMI指数与女性患胰腺癌的风险无关，但与基线四分位数相比，报告体重从其一生最大体重下降大于或等于12.5%的女性患胰腺癌的风险明显降低（or = 0.53, 95% CI 0.29-0.99）。在调整了年龄、居住省份、饮食摄入和人体测量因素后，综合中等和剧烈体力活动指数最高四分位数的男性患胰腺癌的风险降低（OR = 0.53, 95% CI 0.31-0.90）。在女性中，体力活动似乎与胰腺癌无关，尽管剧烈活动水平的增加有降低风险的趋势（趋势p = 0.06）。我们的研究结果支持了胰岛素抵抗是男性和可能女性胰腺肿瘤发展的一个病因因素的假设。(C) 2001 Wiley-Liss, Inc。
To explore the hypothesis that insulin resistance may be an etiologic factor in pancreatic cancer, we assessed the pancreatic cancer risk associated with anthropometric factors and physical activity, both of which are important determinants of insulin sensitivity in humans. Three hundred and twelve patients with histologically confirmed pancreatic cancer were compared to 2,919 controls in a population-based, case-control study in 7 of the 10 Canadian provinces. Participants were asked to report their exposure status for the period 2 years before interview. Men in the highest quartile of body mass index (BMI, greater than or equal to 28.3 kg/m(2)) were at increased risk of pancreatic cancer [adjusted odds ratio (OR) = 1.90, 95% confidence interval (CI) 1.08-3.35]. In addition, men who reported a decrease in weight of at least 2.9% from their lifetime maximum were at reduced risk compared to those reporting a less than or equal to2.9% loss ( greater than or equal to 10.2% loss, OR = 0.51, 95% CI 0.30-0.86). BMI 2 years before interview was not associated with pancreatic cancer risk among women, though those reporting a greater than or equal to 12.5% decrease in weight from their lifetime maximum had substantially lower risk compared to those in the baseline quartile (OR = 0.53, 95% CI 0.29-0.99). After adjustment for age, province of residence, dietary intake and anthropometric factors, men in the highest quartile of the composite moderate and strenuous physical activity index were at reduced risk of pancreatic cancer (OR = 0.53, 95% CI 0.31-0.90). Physical activity did not appear to be associated with pancreatic cancer among women, though a tendency for reduced risk with increasing levels of strenuous activity was suggested (p for trend = 0.06). Our findings support the hypothesis that insulin resistance is an etiologic factor in the development of pancreatic neoplasms among men and possibly women. (C) 2001 Wiley-Liss, Inc.