The effect of curcumin on sepsis-induced acute lung injury in a rat model through the inhibition of the TGF-β1/SMAD3 pathway
The effect of curcumin on sepsis-induced acute lung injury in a rat model through the inhibition of the TGF-β1/SMAD3 pathway
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DOI：
10.1016/j.intimp.2013.03.014
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发表时间：
2013-05-01
影响因子：
5.6
通讯作者：
Liu, Qiong
中科院分区：
文献类型：
--
作者：
Xu, Fang;Lin, Shi-hui;Liu, Qiong
姜黄素具有治疗炎症性疾病的潜力。本研究在大鼠模型中研究了其对脓毒症引起的急性肺损伤（ALI）的影响。 125只健康大鼠随机分为5组，包括正常组、假手术组、脓毒症组、二甲亚砜组、姜黄素治疗组（每组25只）。脓毒症引起的急性肺损伤受到盲肠结扎和穿刺手术的影响。治疗后0、6、12、24和48小时，收获肺用于组织学和蛋白质表达检查。初始治疗24 h后，实时PCR和Western blot分析显示，姜黄素治疗组TGF-β1和SIVIAD3依赖性信号通路的表达较其他对照组显着降低（P < 0.05）。因此，姜黄素在脓毒症诱发的ALI中发挥了保护作用，可能是通过抑制TGF-β1/SIVIAD3通路的表达，这可能为脓毒症诱发的ALL的治疗提供新策略 (C) 2013 Elsevier B.V. 版权所有。
Curcumin has the potential to treat inflammatory diseases. This study investigated its effect on sepsis-induced acute lung injury (ALI) in a rat model. 125 healthy rats were randomly divided into five groups, including normal group, sham-operated group, sepsis group, dimethyl sulfoxide group, and curcumin-treated group (25 rats in each subgroup). Sepsis-induced acute lung injury was affected by cecal ligation and puncture surgery. At 0, 6, 12, 24, and 48 h after treatment, the lungs were harvested for histological and protein expression examinations. 24 h after the initial treatment, real-time PCR and Western blot analysis showed that the expression of TGF-beta 1 and SIVIAD3-dependent signaling pathway was significantly decreased in the curcumin-treated group than other control groups (P < 0.05). Therefore, curcumin played a protective role in sepsis-induced ALI, possibly through the inhibition of the expression of TGF-(beta 1/SIVIAD3 pathway which may provide a new strategy for the treatment of sepsis-induced ALL (C) 2013 Elsevier B.V. All rights reserved.