Genetic dissection of Drosophila adenylate cyclase.
Genetic dissection of Drosophila adenylate cyclase.
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果蝇腺苷酸环化酶的遗传解剖。
DOI：
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发表时间：
1985
影响因子：
11.1
通讯作者：
M. Livingstone
中科院分区：
文献类型：
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作者：
M. Livingstone
果蝇学习突变体芜菁甘蓝缺少腺苷酸环化酶 (EC4.6.1.1) 的钙/钙调蛋白激活。该突变以更精细的分辨率映射到 X 染色体带 12F5-7。通过比较野生型和突变型环化酶活性，可以确定钙敏感和钙不敏感成分对不同配体的相对反应性；总环化酶活性的钙敏感部分对鸟苷酸和单胺的反应明显较低。结果表明，由钙/钙调蛋白（可能是遗传上不同的催化亚基）刺激的环化酶活性成分不与 G 亚基或 G 亚基/单胺受体复合物偶联。
The Drosophila learning mutant rutabaga is missing calcium/calmodulin activation of adenylate cyclase (EC4.6.1.1). The mutation was mapped at a finer resolution to X chromosome bands 12F5-7. By comparing wild-type and mutant cyclase activities, the relative responsiveness of the calcium-sensitive and calcium-insensitive components to different ligands could be determined; the calcium-sensitive fraction of the total cyclase activity was significantly less responsive to guanyl nucleotides and monoamines. The results suggest that the component of cyclase activity that is stimulated by calcium/calmodulin, possibly a genetically distinct catalytic subunit, is not coupled to the G subunit or the G subunit/monoamine receptor complex.
哪些分子步骤决定了海兔短期敏化记忆的时间过程？
DOI：
10.1101/sqb.1983.048.01.084
发表时间：
1983
期刊：
Cold Spring Harbor symposia on quantitative biology
影响因子：
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作者：
Schwartz,JH;Bernier,L;Castellucci,VF;Palazzolo,M;Saitoh,T;Stapleton,A;Kandel,ER
通讯作者：
Kandel,ER