Human Chorionic Gonadotropin and Alpha-Fetoprotein Concentrations in Pregnancy and Maternal Risk of Breast Cancer: A Nested Case-Control Study
Human Chorionic Gonadotropin and Alpha-Fetoprotein Concentrations in Pregnancy and Maternal Risk of Breast Cancer: A Nested Case-Control Study
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DOI：
10.1093/aje/kwn254
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发表时间：
2008-12-01
影响因子：
5
通讯作者：
Lundin, Eva
中科院分区：
文献类型：
--
作者：
Lukanova, Annekatrin;Andersson, Ritu;Lundin, Eva
据信，怀孕激素有助于预防怀孕带来的乳腺癌。作者探讨了母体乳腺癌与人绒毛膜促性腺激素 (hCG) 和甲胎蛋白 (AFP) 的关联。 2001 年，瑞典北部产妇队列开展了一项病例对照研究，该研究正在进行中，自 1975 年以来一直从早孕期孕妇中采集血液样本。病例 (n = 210) 和对照 (n = 357) 的年龄、产次和献血日期进行匹配。通过免疫测定法测量 hCG 和 AFP 的浓度。没有观察到乳腺癌与 hCG 或 AFP 之间存在总体显着关联。然而，在整个研究人群以及采样年龄、产次和癌症诊断年龄的亚组中，hCG 水平处于前三分位数的女性往往比 hCG 水平处于最低三分位数的女性患乳腺癌的风险较低。在癌症诊断的中位滞后时间（>= 14 年；比值比 = 0.53，95% 置信区间：0.27、1.03；P = 0.06）后，在高 hCG 水平的女性中观察到患乳腺癌的风险显着降低。这些发现虽然非常初步，但与乳腺癌风险与怀孕早期循环 hCG 水平升高可能存在的长期保护性关联是一致的。
Pregnancy hormones are believed to be involved in the protection against breast cancer conferred by pregnancy. The authors explored the association of maternal breast cancer with human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP). In 2001, a case-control study was nested within the Northern Sweden Maternity Cohort, an ongoing study in which blood samples have been collected from first-trimester pregnant women since 1975. Cases (n = 210) and controls (n = 357) were matched for age, parity, and date of blood donation. Concentrations of hCG and AFP were measured by immunoassay. No overall significant association of breast cancer with either hCG or AFP was observed. However, women with hCG levels in the top tertile tended to be at lower risk of breast cancer than women with hCG levels in the lowest tertile in the whole study population and in subgroups of age at sampling, parity, and age at cancer diagnosis. A borderline-significant decrease in risk with high hCG levels was observed in women who developed breast cancer after the median lag time to cancer diagnosis (>= 14 years; odds ratio = 0.53, 95% confidence interval: 0.27, 1.03; P = 0.06). These findings, though very preliminary, are consistent with a possible long-term protective association of breast cancer risk with elevated levels of circulating hCG in the early stages of pregnancy.