Epigenetic regulation in hepatocellular carcinoma requires long noncoding RNAs.
Epigenetic regulation in hepatocellular carcinoma requires long noncoding RNAs.
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DOI：
10.1155/2015/473942
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发表时间：
2015
影响因子：
--
通讯作者：
Cicchini C
中科院分区：
文献类型：
--
作者：
Amicone L;Citarella F;Cicchini C
最近的证据证明表观遗传变化与肝细胞癌（HCC）（主要的成人肝脏恶性肿瘤）的发展有关。此外，HCC的发病和进展与几种长非编码RNA（lncRNA）的失调相关，具有重要的生物学意义。正如本综述中所讨论的，许多这些转录本能够通过其作为分子平台的作用特异性地充当肿瘤抑制基因或癌基因。事实上，这些 lncRNA 能够在特定基因组位点上结合并招募表观遗传修饰剂，最终调节与癌症发展相关的基因表达。本综述中提出的证据强调，潜在的靶向治疗方法应考虑 lncRNA 介导的表观遗传调控。
Recent evidence has proven the relevance of epigenetic changes in the development of hepatocellular carcinoma (HCC), the major adult liver malignancy. Moreover, HCC onset and progression correlate with the deregulation of several long noncoding RNAs (lncRNAs), exhibiting great biological significance. As discussed in this review, many of these transcripts are able to specifically act as tumor suppressors or oncogenes by means of their role as molecular platforms. Indeed, these lncRNAs are able to bind and recruit epigenetic modifiers on specific genomic loci, ultimately resulting in regulation of the gene expression relevant in cancer development. The evidence presented in this review highlights that lncRNAs-mediated epigenetic regulation should be taken into account for potential targeted therapeutic approaches.
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影响因子：
8
作者：
Braconi, C.;Kogure, T.;Valeri, N.;Huang, N.;Nuovo, G.;Costinean, S.;Negrini, M.;Miotto, E.;Croce, C. M.;Patel, T.
通讯作者：
Patel, T.
影响因子：
56.9
作者：
Carninci, P;Kasukawa, T;Hayashizaki, Y
通讯作者：
Hayashizaki, Y
影响因子：
17.1
作者：
Andersen JB;Factor VM;Marquardt JU;Raggi C;Lee YH;Seo D;Conner EA;Thorgeirsson SS
通讯作者：
Thorgeirsson SS
影响因子：
10.5
作者：
Cabili, Moran N.;Trapnell, Cole;Rinn, John L.
通讯作者：
Rinn, John L.
影响因子：
64.8
作者：
BARTOLOMEI, MS;ZEMEL, S;TILGHMAN, SM
通讯作者：
TILGHMAN, SM