Obsessive-compulsive symptoms in schizophrenia:: associated clinical features, cognitive function and medication status
Obsessive-compulsive symptoms in schizophrenia:: associated clinical features, cognitive function and medication status
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DOI：
10.1016/j.schres.2004.08.012
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发表时间：
2005-06-15
影响因子：
4.5
通讯作者：
Goff, DC
中科院分区：
文献类型：
--
作者：
Öngür, D;Goff, DC
目的：为了确定一组稳定的门诊精神分裂症患者中强迫（OC）症状的患病率和临床意义，方法：我们研究了118例精神分裂症患者从城市诊所，其特点是使用临床症状量表，包括耶鲁-布朗强迫量表（Y-BOCS），和神经心理学测试。我们将患者分为三组，根据OC症状的严重程度，并采用多元线性回归和卡方检验比较组的变量interests.Results：只有10例（8.8%）的Y-BOCS评分大于16，一个标准的标准，强迫症研究。OC症状最多的患者组（Y-BOCS评分> 11分）在汉密尔顿抑郁量表、阳性与阴性症状量表（PANSS）的阳性症状分量表及其妄想项目上得分高于其他两组，但在任何神经心理学测试上均不高于其他两组。最严重的强迫症状患者（但不是强迫症症状一起，或强迫症单独）更有可能与奥氮平或氯氮平，非典型抗精神病药物治疗先前报告诱导或恶化OC症状。我们的研究结果证实了以前的发现，即精神分裂症和共病OC症状的患者有更多的阳性症状，但并不意味着这些患者比他们的认知障碍更严重。没有OC症状的患者。我们对文献中的差异提出了可能的解释，包括患者采样和合并OC症状定义的差异。最后，我们的数据表明，奥氮平和氯氮平可能会产生或加重某些患者的强迫症;前瞻性研究需要解决这种可能性。(c)2004 Elsevier B. V.保留所有权利。
Objective: To determine the prevalence and clinical significance of obsessive-compulsive (OC) symptoms among a group of stable outpatients with schizophrenia.Methods: We studied 118 patients with schizophrenia from an urban clinic, characterized using clinical symptoms scales, including the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and neuropsychological testing. We categorized patients into three groups according to severity of OC symptoms and used multivariate linear regression and chi-square tests to compare groups on variables of interest.Results: Only 10 patients (8.8%) had Y-BOCS scores greater than 16, a standard criterion for OCD studies. The patient group with the most OC symptoms (Y-BOCS scores > 11) scored higher on the Hamilton Depression Scale, the positive symptoms subscale of the Positive and Negative Syndromes Scale (PANSS) and its delusions item, but not on any of the neuropsychological tests compared to the other two groups. Patients with most severe compulsive symptoms (but not OC symptoms together, or obsessions alone) were more likely to be treated with olanzapine or clozapine, atypical antipsychotic medications previously reported to induce or worsen OC symptoms.Conclusions: Our results confirm previous findings that patients with schizophrenia and comorbid OC symptoms have more positive symptoms but not the suggestion that such patients are more cognitively impaired than their counterparts without OC symptoms. We suggest possible explanations for discrepancies in the literature, including differences in patient sampling and definition of comorbid OC symptoms. Finally, our data suggest that olanzapine and clozapine may produce or worsen compulsions in some patients; prospective studies need to address this possibility. (c) 2004 Elsevier B.V. All rights reserved.