Oxidative Stress, Inflammation, and Vascular Aging in Hypertension
Oxidative Stress, Inflammation, and Vascular Aging in Hypertension
复制标题
DOI：
10.1161/hypertensionaha.117.07802
复制
发表时间：
2017-10-01
期刊：
影响因子：
8.3
通讯作者：
Touyz, Rhian M.
中科院分区：
文献类型：
--
作者：
Guzik, Tomasz J.;Touyz, Rhian M.
Guzik和Touyz血管老化和内皮中的氧化和炎症。[22]血管周围纤维化在很大程度上依赖于免疫细胞，因为它在缺乏成熟T和B细胞的RAG 1 −/−小鼠中得到了预防。[21]这一过程虽然本质上是炎症性的，但似乎是由氧化应激引发的。与此一致，已知降低氧化应激的疗法，如盐皮质激素拮抗剂或血管紧张素转化酶抑制剂，已知可改善血管僵硬加速。23将氧化应激与纤维化联系起来的关键新机制之一涉及小GTP结合蛋白解离刺激剂。他汀类药物上调Rac 1，导致Rac 1降解和氧化应激减少24，并可能减少心脏和血管纤维化。在微循环和大循环中都观察到高血压加速衰老，大血管和微血管系统之间存在重要的串扰。25血压升高，归因于小动脉的功能障碍和重塑，在诱导动脉僵硬中起作用。25，26如上所述，氧化应激和炎症是影响微血管和大血管功能的重要组成部分，引发血压升高、血管重塑、僵硬和持续高血压及其动脉粥样硬化并发症之间的恶性循环。十五二十五二十六
Guzik and Touyz Oxidation and Inflammation in Vascular Aging 661 and endothelium. 22 Perivascular fibrosis is greatly dependent on immune cells because it is prevented in RAG1−/− mice lacking mature T and B cells. 21 This process, although inflammatory in its nature, seems to be initiated by oxidative stress. In line with this, therapies which are known to reduce oxidative stress, such as mineralocorticoid antagonists, or angiotensin-converting enzyme inhibitors, are known to improve vascular stiffness acceleration. 23 One of the key novel mechanisms linking oxidative stress to fibrosis involves small GTP-binding protein dissociation stimulator. Its upregulation by statins results in Rac1 degradation and reduced oxidative stress24 and may reduce cardiac and possibly vascular fibrosis. Accelerated aging in hypertension is observed in both the micro-and macrocirculation, with important cross talk between large vessels and microvasculature. 25 Increased BP, attributed to dysfunction and remodeling of small arterioles, plays a role in inducing arterial stiffness. 25, 26 As discussed above, oxidative stress and inflammation are essential components affecting both micro-and macrovascular function, initiating a vicious circle between increased BP, vascular remodeling, stiffness, and continued hypertension and its atherosclerotic complications. 15, 25, 26