An assessment of cortisol analysis in hair and its clinical applications
An assessment of cortisol analysis in hair and its clinical applications
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DOI：
10.1016/j.forsciint.2009.12.040
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发表时间：
2010-03-20
影响因子：
2.2
通讯作者：
Koren, G.
中科院分区：
文献类型：
--
作者：
Gow, R.;Thomson, S.;Koren, G.
毛发分析外源性化合物，特别是滥用药物，已成为检测长期药物暴露的有用工具。最近，研究深入研究了头发中内源性化合物的暴露。皮质醇是在应激诱导下下丘脑-垂体-肾上腺（HPA）轴激活的肾上腺皮质中合成的。儿茶酚胺通常表示急性压力，皮质醇可以作为亚急性和慢性压力的指标。关于慢性压力影响的研究在本质上往往是主观的，依赖于要求参与者回忆过去压力源的问卷调查。这可能会导致召回和报告偏差的问题。为了更准确地了解慢性应激对身体的影响，需要一种新的客观测量慢性应激的方法。这篇综述使用新出现的证据来描述毛发分析对皮质醇的有用性，并讨论了目前使用的方法。2009爱思唯尔爱尔兰有限公司版权所有。
Hair analyses for exogenous compounds, specifically drugs of abuse, have been a useful tool in detecting long-term drug exposure. More recently, studies have delved into the exposure of endogenous compounds in hair.Cortisol is synthesized in the adrenal cortex in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis. While catecholamines generally indicate acute stress, cortisol can be used as an indicator for sub-acute and chronic stress.Studies on the effects of chronic stress are most often subjective in nature, relying on questionnaires asking the participant to recall on past stressors. This can lead to the issue of recall and reporting bias. A new objective measure of chronic stress is needed for a more accurate understanding of the effects of chronic stress on the body. This review uses emerging evidence to describe the usefulness of hair analysis for cortisol and discusses the current methods used. (C) 2009 Elsevier Ireland Ltd. All rights reserved.