Serine proteinase inhibitors from nematodes and the arms race between host and pathogen.
Serine proteinase inhibitors from nematodes and the arms race between host and pathogen.
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DOI：
10.1016/s0968-0004(00)01761-8
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发表时间：
2001-03
影响因子：
13.8
通讯作者：
X. Zang;R. Maizels
中科院分区：
文献类型：
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作者：
X. Zang;R. Maizels
丝氨酸蛋白酶抑制剂是由一个大的基因家族编码的长期进化的立场。最近发现的寄生虫蛋白，抑制人类丝氨酸蛋白酶，连同完整的基因组序列从秀丽隐杆线虫，提供了一套新的丝氨酸蛋白酶抑制剂从更原始的后生动物，如线虫。结构特征（如反应中心残基），基因组织（包括内含子排列）和抑制功能和目标（如炎症和凝血途径蛋白酶）都有助于重要的新见解蛋白酶抑制剂的演变。一些寄生虫产物已经进化出阻断哺乳动物宿主中的酶，但人类宿主对寄生虫抑制剂产生显著的免疫应答。因此，感染在分子水平上在宿主和病原体之间产生了一种微妙的平衡冲突，这可能加速了这些蛋白质在寄生物种及其宿主中的进化。
Serine proteinase inhibitors are encoded by a large gene family of long evolutionary standing. Recent discoveries of parasite proteins that inhibit human serine proteinases, together with the complete genomic sequence fromCaenorhabditis elegans, have provided a set of new serine proteinase inhibitors from more primitive metazoan animals such as nematodes. The structural features (e.g. reactive centre residues), gene organization (including intron arrangements) and inhibitory function and targets (e.g. inflammatory and coagulation pathway proteinase) all contribute important new insights into proteinase inhibitor evolution. Some parasite products have evolved that block enzymes in the mammalian host, but the human host responds with a significant immune response to the parasite inhibitors. Thus, infection produces a finely balanced conflict between host and pathogen at the molecular level, and this might have accelerated the evolution of these proteins in parasitic species as well as their hosts.