Estimation of Global Aortic Pulse Wave Velocity by Flow-Sensitive 4D MRI
Estimation of Global Aortic Pulse Wave Velocity by Flow-Sensitive 4D MRI
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DOI：
10.1002/mrm.22353
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发表时间：
2010-06-01
影响因子：
3.3
通讯作者：
Harloff, Andreas
中科院分区：
文献类型：
--
作者：
Markl, Michael;Wallis, Wolf;Harloff, Andreas
这项研究的目的是确定血流敏感的四维MRI在评估脉搏波速度方面的价值，作为衡量胸主动脉血管顺应性的指标。12名年轻的健康志愿者与25名有动脉粥样硬化的中风患者和年龄匹配的正常对照组(n=9)进行比较。脉搏波速度计算的结果包含了整个主动脉的速度数据，并与仅基于两个特定解剖地标的血流波形的标准方法进行了比较。动脉粥样硬化组的整体动脉脉搏波速度(7.03±0.24 m/s)高于年龄匹配的对照组(6.40±0.32 m/s)。两者均显著高于年轻志愿者(P<；0.001)(4.39+/-0.32m/s)。年轻志愿者的整体主动脉脉搏波速度与先前报道的MRI研究和导管测量结果一致。对测量误差的估计和误差传播分析表明，在所有46名受试者中，测量的血流波形只有很小的不确定度，主动脉顺应性的中等相对误差低于16%。这些结果证明了利用四维MRI数据的全体积覆盖来计算脉搏波速度的可行性，在动脉粥样硬化患者经常扭曲的主动脉路径上，这也可能是一种优于标准二维技术的优势。《医学评论》63：1575-1582,2010。(C)2010年Wiley-Liss公司
The aim of this study was to determine the value of flow-sensitive four-dimensional MRI for the assessment of pulse wave velocity as a measure of vessel compliance in the thoracic aorta. Findings in 12 young healthy volunteers were compared with those in 25 stroke patients with aortic atherosclerosis and an age-matched normal control group (n = 9). Results from pulse wave velocity calculations incorporated velocity data from the entire aorta and were compared to those of standard methods based on flow waveforms at only two specific anatomic landmarks. Global aortic pulse wave velocity was higher in patients with atherosclerosis (7.03 +/- 0.24 m/sec) compared to age-matched controls (6.40 +/- 0.32 m/sec). Both were significantly (P < 0.001) increased compared to younger volunteers (4.39 +/- 0.32 m/sec). Global aortic pulse wave velocity in young volunteers was in good agreement with previously reported MRI studies and catheter measurements. Estimation of measurement inaccuracies and error propagation analysis demonstrated only minor uncertainties in measured flow waveforms and moderate relative errors below 16% for aortic compliance in all 46 subjects. These results demonstrate the feasibility of pulse wave velocity calculation based on four-dimensional MRI data by exploiting its full volumetric coverage, which may also be an advantage over standard two-dimensional techniques in the often-distorted route of the aorta in patients with atherosclerosis. Magn Reson Med 63:1575-1582, 2010. (C) 2010 Wiley-Liss, Inc.