Regional differences in the response to vasoconstrictor agents of dog and monkey isolated coronary arteries
Regional differences in the response to vasoconstrictor agents of dog and monkey isolated coronary arteries
复制标题
狗和猴离体冠状动脉对血管收缩剂反应的区域差异
DOI：
10.1111/j.1476-5381.1984.tb16471.x
复制
发表时间：
1984
影响因子：
7.3
通讯作者：
N. Toda
中科院分区：
文献类型：
--
作者：
K. Miwa;N. Toda
1比较了犬和猴不同大小的心外膜冠状动脉螺旋条对缩血管剂的收缩反应。KCl（30 mM）引起的大、中、小动脉收缩几乎相同。2 5-羟色胺（5-HT）（10 - 9 - 2 × 10 - 6 M）引起的收缩在犬中为大动脉>中动脉>小动脉，在猴中为大动脉=中动脉>小动脉。Cinanserin抑制了这些反应。[3]相比之下，血管紧张素II（AII）（10−7 M）引起的收缩在狗中的顺序是小动脉>中动脉>大动脉，在猴子中的顺序是小动脉>中动脉=大动脉。Sar 1-Ala 8-血管紧张素II显著减弱肽诱导的收缩。4前列腺素F2α（PGF 2 α）对犬大、中型动脉的收缩作用明显大于对小动脉的收缩作用，而对猴不同大小动脉的收缩作用无明显差异。在狗和猴子的不同大小的动脉中，碳环血栓烷A2（c-TXA 2）诱导的收缩没有差异。5这些结果表明，5-HT受体的敏感性和/或群体在近端冠状动脉中比在远端动脉中更大，而相反，AII受体的敏感性和/或群体在远端冠状动脉中更大。PGF 2 α和c-TXA 2受体在不同大小的猴动脉中的反应程度相似，尽管PGF 2 α受体在犬冠状动脉远端的反应程度较低。
1 Contractile responses to vasoconstrictor agents were compared in helical strips of dog and monkey epicardial coronary arteries of different sizes. Contractions of large, medium and small arteries induced by KCl (30mM) were virtually identical. 2 Contractions induced by 5‐hydroxytryptamine (5‐HT) (10−9‐2 × 10−6 M) were in the order of large > medium > small arteries in dogs, and large = medium > small arteries in monkeys. Cinanserin suppressed these responses. 3 In contrast, contractions produced by angiotensin II (AII) (10−7 M) were in the order of small > medium > large arteries in dogs, and small > medium = large arteries in monkeys. Sar1‐Ala8‐angiotensin II markedly attenuated the peptide‐induced contractions. 4 Contractions induced by prostaglandin F2α (PGF2α) were significantly greater in large and medium sized arteries than in small arteries in dogs, while those of the arteries of different sizes isolated from monkeys did not differ. Contractions induced by carbocyclic thromboxane A2 (c‐TXA2), in arteries of different sizes in dogs and monkeys, did not differ. 5 These results suggest that the sensitivity and/or the population of 5‐HT receptors are greater in proximal coronary arteries than in distal arteries, while, in contrast, the sensitivity and/or population of AII receptors are greater in distal coronary arteries. Receptors for PGF2α and c‐TXA2 appear to react to a similar degree in monkey arteries of different sizes, although receptors for PGF2α appear to be fewer in distal coronary arteries in dogs.