Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide.: Part 2:: Synthesis of fragments C1-6 and C9-14
Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide.: Part 2:: Synthesis of fragments C1-6 and C9-14
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DOI：
10.1021/op0341317
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发表时间：
2004-01-01
影响因子：
3.4
通讯作者：
Gamboni, R
中科院分区：
文献类型：
--
作者：
Mickel, SJ;Sedelmeier, GH;Gamboni, R
描述了从共同前体3千克规模合成（+）-盘皮内酯片段C1-6（6）和C9-14（4）。通过最小化或消除在Smith合成中分离和表征的副产物的形成，开发了两种片段的每个步骤的改进程序。
Kilogram-scale syntheses of fragments C1-6 (6) and C9-14 (4) of (+)-discodermolide from common precursor 3 are described. Improved procedures for each step of both fragments were developed by minimizing or eliminating the formation of byproducts that were isolated and characterized in Smith's synthesis.