Synthesis of the 1-Amino-Alditols Derived from Cellobiose, Lactose and Maltose. A Comprehensive NMR Study of Some Alditols and Amino-Alditols
Synthesis of the 1-Amino-Alditols Derived from Cellobiose, Lactose and Maltose. A Comprehensive NMR Study of Some Alditols and Amino-Alditols
复制标题
由纤维二糖、乳糖和麦芽糖衍生的 1-氨基-糖醇的合成。
DOI：
10.1080/07328309208018272
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发表时间：
1992
影响因子：
1
通讯作者：
K. Bock
中科院分区：
文献类型：
--
作者：
I. Christiansen;M. Meldal;K. Bock
以纤维二糖、乳糖和麦芽糖为原料，经苄胺还原胺化，然后在常压氢气下催化脱除苄基，合成了克量的1 -氨基糖醇，产率为80-90%。用NMR对1 -氨基糖醇、纤维二糖、乳糖和六种低聚木糖（d.p.2 -7）的直接还原产物进行了表征。结合1D 1H和13 C光谱以及2D 1H−1H COSY和13 C −1H相关实验进行了归属和分析。给出了氨基糖醇的13 C化学位移pH滴定曲线。
Abstract Gram quantities of the 1 -amino-alditols derived from cellobiose, lactose and maltose were synthesized in 80–90% yield via a reductive amination with benzylamine and subsequent catalytic removal of the benzyl group at atmospheric hydrogen pressure. The 1 -amino-alditols together with the products from direct reduction of cellobiose, lactose and six rnaltooligosaccharides (d.p. 2–7) were fully characterized by NMR. Assignment and analysis was done from a combination of 1D 1H and 13C spectra and 2D 1H−1H COSY and 13C−1H correlation experiments.13C chemical shift pH titration curves for the amino-alditols are Presented.