Do brain responses to emotional images and cigarette cues differ? An fMRI study in smokers.
Do brain responses to emotional images and cigarette cues differ? An fMRI study in smokers.
复制标题
大脑对情感图像和香烟线索的反应是否不同？
DOI：
10.1111/j.1460-9568.2011.07915.x
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Cinciripini,PaulM
中科院分区：
文献类型：
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作者：
Versace,Francesco;Engelmann,JeffreyM;Jackson,EdwardF;Costa,VincentD;Robinson,JasonD;Lam,ChoY;Minnix,JenniferA;Brown,VictoriaL;Wetter,DavidW;Cinciripini,PaulM
长期吸烟被认为会导致大脑奖励系统的变化，导致与香烟相关的刺激被高估，自然奖励被低估。我们测试了以下假设：在吸烟者中，参与情绪处理的大脑回路：(I)在接触与香烟相关的图片时比接触中性图片时更活跃；(Ii)与与香烟相关的图片相比，可能不那么活跃到令人愉悦，这表明本质上令人愉快的刺激有所减弱。我们获得了35名吸烟者在呈现愉快(色情和浪漫)、不愉快(伤残和悲伤)、中性和与香烟相关的图片时的全脑血氧水平依赖(BOLD)功能磁共振成像数据。全脑分析显示，在呈现与香烟相关的图片时，相对于次级视觉区域、扣带回、额叶回、背侧纹状体和左侧脑岛的中性图片，大胆反应明显更大。在除脑岛以外的所有集群中，对色情图片的大胆反应都超过了对与香烟相关的图片的反应。在左侧脑岛，我们观察到对与香烟相关的图片的大胆反应比对所有其他图片类别的反应更大。除了中性的图片外，通过包括本质上令人愉快和不愉快的图片，我们能够得出结论，与香烟相关的图片的呈现激活了支持情绪过程的大脑区域，但我们没有发现证据表明，在存在本质上令人愉快的刺激时，大脑奖励系统的激活总体上减少了。
Chronic smoking is thought to cause changes in brain reward systems that result in overvaluation of cigarette‐related stimuli and undervaluation of natural rewards. We tested the hypotheses that, in smokers, brain circuits involved in emotional processing: (i) would be more active during exposure to cigarette‐related than neutral pictures; and (ii) would be less active to pleasant compared with cigarette‐related pictures, suggesting a devaluation of intrinsically pleasant stimuli. We obtained whole‐brain blood oxygenation level‐dependent (BOLD) functional magnetic resonance imaging data from 35 smokers during the presentation of pleasant (erotica and romance), unpleasant (mutilations and sad), neutral, and cigarette‐related pictures. Whole‐brain analyses showed significantly larger BOLD responses during presentation of cigarette‐related pictures relative to neutral ones within the secondary visual areas, the cingulate gyrus, the frontal gyrus, the dorsal striatum, and the left insula. BOLD responses to erotic pictures exceeded responses to cigarette‐related pictures in all clusters except the insula. Within the left insula we observed larger BOLD responses to cigarette‐related pictures than to all other picture categories. By including intrinsically pleasant and unpleasant pictures in addition to neutral ones, we were able to conclude that the presentation of cigarette‐related pictures activates brain areas supporting emotional processes, but we did not find evidence of overall reduced activation of the brain reward systems in the presence of intrinsically pleasant stimuli.